ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Signal recognition particle subunit SRP54

Intramolecular
Cysteine 118 and cysteine 136
Cysteine 133 and cysteine 136
A redox-regulated disulphide may form within Signal recognition particle subunit SRP54 between cysteines 118 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
5l3q
Structure name
structure of the gtpase heterodimer of human srp54 and sralpha
Structure deposition date
2016-05-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
99
Minimum pKa ?
12
% buried
100
Peptide accession
P61011
Residue number A
118
Residue number B
136
Peptide name
Signal recognition particle subunit SRP54

Ligandability

Cysteine 118 of Signal recognition particle subunit SRP54

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of Signal recognition particle subunit SRP54

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Signal recognition particle subunit SRP54 between cysteines 133 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
2j37
Structure name
model of mammalian srp bound to 80s rncs
Structure deposition date
2006-08-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
76
Peptide accession
P61010
Residue number A
133
Residue number B
136
Peptide name
Signal recognition particle subunit SRP54

Ligandability

Cysteine 133 of Signal recognition particle subunit SRP54

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of Signal recognition particle subunit SRP54

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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