ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Actin-related protein 3

Intramolecular
Cysteine 189 and cysteine 307
Cysteine 394 and cysteine 408
A redox-regulated disulphide may form within Actin-related protein 3 between cysteines 189 and 307.

Details

Redox score ?
84
PDB code
4xei
Structure name
orthorhombic isomorph of bovine arp2/3 complex
Structure deposition date
2014-12-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
64
Peptide accession
P61157
Residue number A
189
Residue number B
307
Peptide name
Actin-related protein 3

Ligandability

Cysteine 189 of Actin-related protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Actin-related protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 3 between cysteines 394 and 408. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
1tyq
Structure name
crystal structure of arp2/3 complex with bound atp and calcium
Structure deposition date
2004-07-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
92
Peptide accession
P61157
Residue number A
394
Residue number B
408
Peptide name
Actin-related protein 3

Ligandability

Cysteine 394 of Actin-related protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 408 of Actin-related protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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