ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Actin-related protein 2

Intramolecular
Cysteine 11 and cysteine 20 L
A redox-regulated disulphide may form within Actin-related protein 2 between cysteines 11 and 20. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2p9i
Structure name
crystal structure of bovine arp2/3 complex co-crystallized with adp and crosslinked with gluteraldehyde
Structure deposition date
2007-03-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
32
Peptide accession
A7MB62
Residue number A
11
Residue number B
20
Peptide name
Actin-related protein 2

Ligandability

Cysteine 11 of Actin-related protein 2

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 20 of Actin-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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