ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rho-related GTP-binding protein RhoE

Intramolecular
Cysteine 24 and cysteine 197
Cysteine 135 and cysteine 177
Cysteine 101 and cysteine 135
Cysteine 34 and cysteine 135
Cysteine 34 and cysteine 101
Cysteine 101 and cysteine 177
Cysteine 34 and cysteine 177
A redox-regulated disulphide may form within Rho-related GTP-binding protein RhoE between cysteines 24 and 197.

Details

Redox score ?
79
PDB code
2v55
Structure name
mechanism of multi-site phosphorylation from a rock-i:rhoe complex structure
Structure deposition date
2008-10-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
68
Minimum pKa ?
8
% buried
63
Peptide accession
P61587
Residue number A
24
Residue number B
197
Peptide name
Rho-related GTP-binding protein RhoE

Ligandability

Cysteine 24 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho-related GTP-binding protein RhoE between cysteines 135 and 177.

Details

Redox score ?
72
PDB code
1gwn
Structure name
the crystal structure of the core domain of rhoe/rnd3 - a constitutively activated small g protein
Structure deposition date
2002-03-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
5
% buried
100
Peptide accession
P61588
Residue number A
135
Residue number B
177
Peptide name
Rho-related GTP-binding protein RhoE

Ligandability

Cysteine 135 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho-related GTP-binding protein RhoE between cysteines 101 and 135.

Details

Redox score ?
70
PDB code
1gwn
Structure name
the crystal structure of the core domain of rhoe/rnd3 - a constitutively activated small g protein
Structure deposition date
2002-03-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
99
Minimum pKa ?
5
% buried
100
Peptide accession
P61588
Residue number A
101
Residue number B
135
Peptide name
Rho-related GTP-binding protein RhoE

Ligandability

Cysteine 101 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 135 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho-related GTP-binding protein RhoE between cysteines 34 and 135.

Details

Redox score ?
66
PDB code
1gwn
Structure name
the crystal structure of the core domain of rhoe/rnd3 - a constitutively activated small g protein
Structure deposition date
2002-03-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
88
Minimum pKa ?
5
% buried
100
Peptide accession
P61588
Residue number A
34
Residue number B
135
Peptide name
Rho-related GTP-binding protein RhoE

Ligandability

Cysteine 34 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 135 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho-related GTP-binding protein RhoE between cysteines 34 and 101. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2v55
Structure name
mechanism of multi-site phosphorylation from a rock-i:rhoe complex structure
Structure deposition date
2008-10-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
88
Minimum pKa ?
14
% buried
100
Peptide accession
P61587
Residue number A
34
Residue number B
101
Peptide name
Rho-related GTP-binding protein RhoE

Ligandability

Cysteine 34 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho-related GTP-binding protein RhoE between cysteines 101 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
1gwn
Structure name
the crystal structure of the core domain of rhoe/rnd3 - a constitutively activated small g protein
Structure deposition date
2002-03-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
94
Minimum pKa ?
18
% buried
100
Peptide accession
P61588
Residue number A
101
Residue number B
177
Peptide name
Rho-related GTP-binding protein RhoE

Ligandability

Cysteine 101 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho-related GTP-binding protein RhoE between cysteines 34 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
1gwn
Structure name
the crystal structure of the core domain of rhoe/rnd3 - a constitutively activated small g protein
Structure deposition date
2002-03-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
14
% buried
100
Peptide accession
P61588
Residue number A
34
Residue number B
177
Peptide name
Rho-related GTP-binding protein RhoE

Ligandability

Cysteine 34 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Rho-related GTP-binding protein RhoE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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