ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Prefoldin subunit 3

Intermolecular
Cysteine 70 of Prefoldin subunit 2 and cysteine 124
Cysteine 113 and cysteine 49 of Prefoldin subunit 5
A redox-regulated disulphide may form between cysteine 70 of Prefoldin subunit 2 and cysteine 124 of Prefoldin subunit 3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7wu7
Structure name
prefoldin-tubulin-tric complex
Structure deposition date
2022-02-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
74
Peptide A name
Prefoldin subunit 2
Peptide B name
Prefoldin subunit 3
Peptide A accession
Q9UHV9
Peptide B accession
P61758
Peptide A residue number
70
Peptide B residue number
124

Ligandability

Cysteine 70 of Prefoldin subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Prefoldin subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 113 of Prefoldin subunit 3 and cysteine 49 of Prefoldin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
6nr9
Structure name
htric-hpfd class5
Structure deposition date
2019-01-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
14
% buried
100
Peptide A name
Prefoldin subunit 3
Peptide B name
Prefoldin subunit 5
Peptide A accession
P61758
Peptide B accession
Q99471
Peptide A residue number
113
Peptide B residue number
49

Ligandability

Cysteine 113 of Prefoldin subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 49 of Prefoldin subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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