ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Intermolecular
Cysteine 241 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A and cysteine 72
Cysteine 277 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A and cysteine 72
Cysteine 245 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A and cysteine 72
A redox-regulated disulphide may form between cysteine 241 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A and cysteine 72 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6s7o
Structure name
cryo-em structure of human oligosaccharyltransferase complex ost-a
Structure deposition date
2019-07-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide A name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Peptide B name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Peptide A accession
P46977
Peptide B accession
P61803
Peptide A residue number
241
Peptide B residue number
72

Ligandability

Cysteine 241 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 277 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A and cysteine 72 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6s7o
Structure name
cryo-em structure of human oligosaccharyltransferase complex ost-a
Structure deposition date
2019-07-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
92
Peptide A name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Peptide B name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Peptide A accession
P46977
Peptide B accession
P61803
Peptide A residue number
277
Peptide B residue number
72

Ligandability

Cysteine 277 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 245 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A and cysteine 72 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6s7o
Structure name
cryo-em structure of human oligosaccharyltransferase complex ost-a
Structure deposition date
2019-07-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide A name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Peptide B name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Peptide A accession
P46977
Peptide B accession
P61803
Peptide A residue number
245
Peptide B residue number
72

Ligandability

Cysteine 245 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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