ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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WD repeat-containing protein 5

Intermolecular
Cysteine 261 and cysteine 23 of ORF 73
Cysteine 134 and cysteine 23 of ORF 73
Intramolecular
Cysteine 309 and cysteine 334
Cysteine 195 and cysteine 205
Cysteine 134 and cysteine 135
Cysteine 195 and cysteine 248
Cysteine 134 and cysteine 261
A redox-regulated disulphide may form between cysteine 261 of WD repeat-containing protein 5 and cysteine 23 of ORF 73. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7bcy
Structure name
x-ray structure of wdr5delta24 bound to the kaposi's sarcoma herpesvirus lana win motif peptide
Structure deposition date
2020-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
100
Peptide A name
WD repeat-containing protein 5
Peptide B name
ORF 73
Peptide A accession
P61964
Peptide B accession
Q76SB0
Peptide A residue number
261
Peptide B residue number
23

Ligandability

Cysteine 261 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 23 of ORF 73

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 134 of WD repeat-containing protein 5 and cysteine 23 of ORF 73. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7bcy
Structure name
x-ray structure of wdr5delta24 bound to the kaposi's sarcoma herpesvirus lana win motif peptide
Structure deposition date
2020-12-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
12
% buried
96
Peptide A name
WD repeat-containing protein 5
Peptide B name
ORF 73
Peptide A accession
P61964
Peptide B accession
Q76SB0
Peptide A residue number
134
Peptide B residue number
23

Ligandability

Cysteine 134 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 23 of ORF 73

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 5 between cysteines 309 and 334. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2co0
Structure name
wdr5 and unmodified histone h3 complex at 2
Structure deposition date
2006-05-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
62
Peptide accession
P61964
Residue number A
309
Residue number B
334
Peptide name
WD repeat-containing protein 5

Ligandability

Cysteine 309 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 334 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 5 between cysteines 195 and 205. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4gmb
Structure name
crystal structure of human wd repeat domain 5 with compound mm-402
Structure deposition date
2012-08-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
66
Peptide accession
P61964
Residue number A
195
Residue number B
205
Peptide name
WD repeat-containing protein 5

Ligandability

Cysteine 195 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 5 between cysteines 134 and 135. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
2xl2
Structure name
wdr5 in complex with an rbbp5 peptide recruited to novel site
Structure deposition date
2010-07-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
13
% buried
100
Peptide accession
P61965
Residue number A
134
Residue number B
135
Peptide name
WD repeat-containing protein 5

Ligandability

Cysteine 134 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 135 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 5 between cysteines 195 and 248. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6pww
Structure name
cryo-em structure of mll1 in complex with rbbp5 and wdr5 bound to the nucleosome
Structure deposition date
2019-07-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
76
Peptide accession
P61964
Residue number A
195
Residue number B
248
Peptide name
WD repeat-containing protein 5

Ligandability

Cysteine 195 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 5 between cysteines 134 and 261. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
5vfc
Structure name
wdr5 bound to inhibitor mm-589
Structure deposition date
2017-04-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
100
Peptide accession
P61964
Residue number A
134
Residue number B
261
Peptide name
WD repeat-containing protein 5

Ligandability

Cysteine 134 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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