ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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LIM domain transcription factor LMO4

Intramolecular
Cysteine 87 and cysteine 90
Cysteine 23 and cysteine 26
Cysteine 115 and cysteine 118
Cysteine 87 and cysteine 112
Cysteine 23 and cysteine 47
Cysteine 115 and cysteine 137
Cysteine 50 and cysteine 73
Cysteine 50 and cysteine 53
Cysteine 26 and cysteine 47
Cysteine 90 and cysteine 112
More...
Cysteine 118 and cysteine 137
Cysteine 53 and cysteine 73
A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 87 and 90.

Details

Redox score ?
85
PDB code
2dfy
Structure name
crystal structure of a cyclized protein fusion of lmo4 lim domains 1 and 2 with the lim interacting domain of ldb1
Structure deposition date
2006-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
10
Peptide accession
P61969
Residue number A
87
Residue number B
90
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 87 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 23 and 26.

Details

Redox score ?
84
PDB code
2l4z
Structure name
nmr structure of fusion of ctip (641-685) to lmo4-lim1 (18-82)
Structure deposition date
2010-10-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
4
Peptide accession
P61968
Residue number A
23
Residue number B
26
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 23 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 26 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 115 and 118.

Details

Redox score ?
83
PDB code
2dfy
Structure name
crystal structure of a cyclized protein fusion of lmo4 lim domains 1 and 2 with the lim interacting domain of ldb1
Structure deposition date
2006-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
7
% buried
9
Peptide accession
P61969
Residue number A
115
Residue number B
118
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 115 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 87 and 112.

Details

Redox score ?
83
PDB code
2dfy
Structure name
crystal structure of a cyclized protein fusion of lmo4 lim domains 1 and 2 with the lim interacting domain of ldb1
Structure deposition date
2006-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
6
% buried
12
Peptide accession
P61969
Residue number A
87
Residue number B
112
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 87 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 23 and 47.

Details

Redox score ?
82
PDB code
2l4z
Structure name
nmr structure of fusion of ctip (641-685) to lmo4-lim1 (18-82)
Structure deposition date
2010-10-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
16
Peptide accession
P61968
Residue number A
23
Residue number B
47
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 23 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 115 and 137.

Details

Redox score ?
81
PDB code
2dfy
Structure name
crystal structure of a cyclized protein fusion of lmo4 lim domains 1 and 2 with the lim interacting domain of ldb1
Structure deposition date
2006-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
12
Peptide accession
P61969
Residue number A
115
Residue number B
137
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 115 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 50 and 73.

Details

Redox score ?
80
PDB code
2l4z
Structure name
nmr structure of fusion of ctip (641-685) to lmo4-lim1 (18-82)
Structure deposition date
2010-10-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
6
% buried
15
Peptide accession
P61968
Residue number A
50
Residue number B
73
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 50 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 73 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 50 and 53.

Details

Redox score ?
78
PDB code
2dfy
Structure name
crystal structure of a cyclized protein fusion of lmo4 lim domains 1 and 2 with the lim interacting domain of ldb1
Structure deposition date
2006-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
27
Peptide accession
P61969
Residue number A
50
Residue number B
53
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 50 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 53 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 26 and 47.

Details

Redox score ?
77
PDB code
2l4z
Structure name
nmr structure of fusion of ctip (641-685) to lmo4-lim1 (18-82)
Structure deposition date
2010-10-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
12
Peptide accession
P61968
Residue number A
26
Residue number B
47
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 26 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 90 and 112.

Details

Redox score ?
77
PDB code
2dfy
Structure name
crystal structure of a cyclized protein fusion of lmo4 lim domains 1 and 2 with the lim interacting domain of ldb1
Structure deposition date
2006-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
3
Peptide accession
P61969
Residue number A
90
Residue number B
112
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 90 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 118 and 137.

Details

Redox score ?
76
PDB code
2dfy
Structure name
crystal structure of a cyclized protein fusion of lmo4 lim domains 1 and 2 with the lim interacting domain of ldb1
Structure deposition date
2006-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
3
Peptide accession
P61969
Residue number A
118
Residue number B
137
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 118 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LIM domain transcription factor LMO4 between cysteines 53 and 73.

Details

Redox score ?
75
PDB code
2l4z
Structure name
nmr structure of fusion of ctip (641-685) to lmo4-lim1 (18-82)
Structure deposition date
2010-10-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
6
Peptide accession
P61968
Residue number A
53
Residue number B
73
Peptide name
LIM domain transcription factor LMO4

Ligandability

Cysteine 53 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 73 of LIM domain transcription factor LMO4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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