ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Ubiquitin carboxyl-terminal hydrolase 46

Intermolecular
Cysteine 366 of WD repeat-containing protein 48 and cysteine 233
Intramolecular
Cysteine 229 and cysteine 232
Cysteine 185 and cysteine 229
Cysteine 182 and cysteine 229
Cysteine 182 and cysteine 185
Cysteine 182 and cysteine 232
Cysteine 229 and cysteine 233
Cysteine 185 and cysteine 232
Cysteine 232 and cysteine 233
Cysteine 44 and cysteine 46
More...
Cysteine 185 and cysteine 233
Cysteine 44 and cysteine 305
A redox-regulated disulphide may form between cysteine 366 of WD repeat-containing protein 48 and cysteine 233 of Ubiquitin carboxyl-terminal hydrolase 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
5cvn
Structure name
wdr48 (2-580):usp46~ubiquitin ternary complex
Structure deposition date
2015-07-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
90
Peptide A name
WD repeat-containing protein 48
Peptide B name
Ubiquitin carboxyl-terminal hydrolase 46
Peptide A accession
Q8TAF3
Peptide B accession
P62068
Peptide A residue number
366
Peptide B residue number
233

Ligandability

Cysteine 366 of WD repeat-containing protein 48

Cysteine 233 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 229 and 232.

Details

Redox score ?
91
PDB code
6jlq
Structure name
crystal structure of human usp46-wdr48-wdr20 complex
Structure deposition date
2019-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
1
% buried
64
Peptide accession
P62068
Residue number A
229
Residue number B
232
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 229 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 232 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 185 and 229.

Details

Redox score ?
87
PDB code
5cvm
Structure name
usp46~ubiquitin bea covalent complex
Structure deposition date
2015-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
4
Peptide accession
P62068
Residue number A
185
Residue number B
229
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 185 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 229 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 182 and 229.

Details

Redox score ?
82
PDB code
5cvn
Structure name
wdr48 (2-580):usp46~ubiquitin ternary complex
Structure deposition date
2015-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
5
% buried
85
Peptide accession
P62068
Residue number A
182
Residue number B
229
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 182 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 229 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 182 and 185.

Details

Redox score ?
80
PDB code
5cvo
Structure name
wdr48:usp46~ubiquitin ternary complex
Structure deposition date
2015-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
5
% buried
nan
Peptide accession
P62068
Residue number A
182
Residue number B
185
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 182 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 185 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 182 and 232.

Details

Redox score ?
79
PDB code
5cvn
Structure name
wdr48 (2-580):usp46~ubiquitin ternary complex
Structure deposition date
2015-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
5
% buried
98
Peptide accession
P62068
Residue number A
182
Residue number B
232
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 182 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 232 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 229 and 233.

Details

Redox score ?
67
PDB code
6jlq
Structure name
crystal structure of human usp46-wdr48-wdr20 complex
Structure deposition date
2019-03-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
1
% buried
48
Peptide accession
P62068
Residue number A
229
Residue number B
233
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 229 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 233 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 185 and 232. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6jlq
Structure name
crystal structure of human usp46-wdr48-wdr20 complex
Structure deposition date
2019-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
22
% buried
nan
Peptide accession
P62068
Residue number A
185
Residue number B
232
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 185 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 232 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 232 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5cvn
Structure name
wdr48 (2-580):usp46~ubiquitin ternary complex
Structure deposition date
2015-07-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
90
Peptide accession
P62068
Residue number A
232
Residue number B
233
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 232 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 233 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 44 and 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6jlq
Structure name
crystal structure of human usp46-wdr48-wdr20 complex
Structure deposition date
2019-03-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
10
% buried
76
Peptide accession
P62068
Residue number A
44
Residue number B
46
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 44 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 46 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 185 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
5cvo
Structure name
wdr48:usp46~ubiquitin ternary complex
Structure deposition date
2015-07-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
nan
Peptide accession
P62068
Residue number A
185
Residue number B
233
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 185 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 233 of Ubiquitin carboxyl-terminal hydrolase 46

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 46 between cysteines 44 and 305. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
5cvo
Structure name
wdr48:usp46~ubiquitin ternary complex
Structure deposition date
2015-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
11
% buried
96
Peptide accession
P62068
Residue number A
44
Residue number B
305
Peptide name
Ubiquitin carboxyl-terminal hydrolase 46

Ligandability

Cysteine 44 of Ubiquitin carboxyl-terminal hydrolase 46

Cysteine 305 of Ubiquitin carboxyl-terminal hydrolase 46

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