ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Mitochondrial import inner membrane translocase subunit Tim10

Intramolecular
Cysteine 33 and cysteine 50 L
Cysteine 29 and cysteine 54
Cysteine 33 and cysteine 54
Cysteine 29 and cysteine 33
Cysteine 50 and cysteine 54 L
Cysteine 29 and cysteine 50 L
A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 between cysteines 33 and 50.

Details

Redox score ?
83
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P62072
Residue number A
33
Residue number B
50
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10

Ligandability

Cysteine 33 of Mitochondrial import inner membrane translocase subunit Tim10

Cysteine 50 of Mitochondrial import inner membrane translocase subunit Tim10

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 between cysteines 29 and 54.

Details

Redox score ?
82
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P62072
Residue number A
29
Residue number B
54
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10

Ligandability

Cysteine 29 of Mitochondrial import inner membrane translocase subunit Tim10

Cysteine 54 of Mitochondrial import inner membrane translocase subunit Tim10

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 between cysteines 33 and 54.

Details

Redox score ?
66
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P62072
Residue number A
33
Residue number B
54
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10

Ligandability

Cysteine 33 of Mitochondrial import inner membrane translocase subunit Tim10

Cysteine 54 of Mitochondrial import inner membrane translocase subunit Tim10

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 between cysteines 29 and 33.

Details

Redox score ?
63
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P62072
Residue number A
29
Residue number B
33
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10

Ligandability

Cysteine 29 of Mitochondrial import inner membrane translocase subunit Tim10

Cysteine 33 of Mitochondrial import inner membrane translocase subunit Tim10

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 between cysteines 50 and 54. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P62072
Residue number A
50
Residue number B
54
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10

Ligandability

Cysteine 50 of Mitochondrial import inner membrane translocase subunit Tim10

Cysteine 54 of Mitochondrial import inner membrane translocase subunit Tim10

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 between cysteines 29 and 50. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P62072
Residue number A
29
Residue number B
50
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10

Ligandability

Cysteine 29 of Mitochondrial import inner membrane translocase subunit Tim10

Cysteine 50 of Mitochondrial import inner membrane translocase subunit Tim10

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