a tool for identifying drug-targetable redox-active disulphides

26S proteasome regulatory subunit 4

Intermolecular

Cysteine 236 of 26S proteasome non-ATPase regulatory subunit 2 and cysteine 58 L

A redox-regulated disulphide may form between cysteine 236 of 26S proteasome non-ATPase regulatory subunit 2 and cysteine 58 of 26S proteasome regulatory subunit 4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

56

PDB code

Structure name

ground state 26s proteasome (gs2)

Structure deposition date

2017-10-11

Thiol separation (Å)

7

Half-sphere exposure sum ?

61

Minimum pK_a ?

8

% buried

80

Peptide A name

26S proteasome non-ATPase regulatory subunit 2

Peptide B name

26S proteasome regulatory subunit 4

Peptide A accession

Peptide B accession

Peptide A residue number

236

Peptide B residue number

58

Ligandability

Cysteine 236 of 26S proteasome non-ATPase regulatory subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 58 of 26S proteasome regulatory subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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