ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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40S ribosomal protein S14

Intramolecular
Cysteine 54 and cysteine 85
Cysteine 31 and cysteine 85
Cysteine 31 and cysteine 54
A redox-regulated disulphide may form within 40S ribosomal protein S14 between cysteines 54 and 85. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6g5i
Structure name
cryo-em structure of a late human pre-40s ribosomal subunit - state r
Structure deposition date
2018-03-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
11
% buried
91
Peptide accession
P62263
Residue number A
54
Residue number B
85
Peptide name
40S ribosomal protein S14

Ligandability

Cysteine 54 of 40S ribosomal protein S14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of 40S ribosomal protein S14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 40S ribosomal protein S14 between cysteines 31 and 85. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7wtx
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b1
Structure deposition date
2022-02-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
94
Peptide accession
P62263
Residue number A
31
Residue number B
85
Peptide name
40S ribosomal protein S14

Ligandability

Cysteine 31 of 40S ribosomal protein S14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of 40S ribosomal protein S14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 40S ribosomal protein S14 between cysteines 31 and 54. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7wts
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state utp14
Structure deposition date
2022-02-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
96
Peptide accession
P62263
Residue number A
31
Residue number B
54
Peptide name
40S ribosomal protein S14

Ligandability

Cysteine 31 of 40S ribosomal protein S14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of 40S ribosomal protein S14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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