a tool for identifying drug-targetable redox-active disulphides

40S ribosomal protein S11

Intramolecular

Cysteine 60 and cysteine 116 L

A redox-regulated disulphide may form within 40S ribosomal protein S11 between cysteines 60 and 116.

Details

Redox score ?

72

PDB code

Structure name

cryo-em structure of a late human pre-40s ribosomal subunit - mature

Structure deposition date

2018-03-29

Thiol separation (Å)

4

Half-sphere exposure sum ?

71

Minimum pK_a ?

6

% buried

88

Peptide accession

Residue number A

60

Residue number B

116

Peptide name

40S ribosomal protein S11

Ligandability

Cysteine 60 of 40S ribosomal protein S11

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 116 of 40S ribosomal protein S11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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