ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Small nuclear ribonucleoprotein F

Intermolecular
Cysteine 63 of Small nuclear ribonucleoprotein Sm D2 and cysteine 66
A redox-regulated disulphide may form between cysteine 63 of Small nuclear ribonucleoprotein Sm D2 and cysteine 66 of Small nuclear ribonucleoprotein F (2063 and 4066 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4f7u
Structure name
the 6s snrnp assembly intermediate
Structure deposition date
2012-05-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
94
Peptide A name
Small nuclear ribonucleoprotein Sm D2
Peptide B name
Small nuclear ribonucleoprotein F
Peptide A accession
P62317
Peptide B accession
P62321
Peptide A residue number
63
Peptide B residue number
66

Ligandability

Cysteine 63 of Small nuclear ribonucleoprotein Sm D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Small nuclear ribonucleoprotein F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: