ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Small nuclear ribonucleoprotein Sm D2

Intermolecular
Cysteine 63 and cysteine 66 of Small nuclear ribonucleoprotein F
Intramolecular
Cysteine 46 and cysteine 63
A redox-regulated disulphide may form between cysteine 63 of Small nuclear ribonucleoprotein Sm D2 and cysteine 66 of Small nuclear ribonucleoprotein F (2063 and 4066 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4f7u
Structure name
the 6s snrnp assembly intermediate
Structure deposition date
2012-05-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
94
Peptide A name
Small nuclear ribonucleoprotein Sm D2
Peptide B name
Small nuclear ribonucleoprotein F
Peptide A accession
P62317
Peptide B accession
P62321
Peptide A residue number
63
Peptide B residue number
66

Ligandability

Cysteine 63 of Small nuclear ribonucleoprotein Sm D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Small nuclear ribonucleoprotein F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Small nuclear ribonucleoprotein Sm D2 between cysteines 46 and 63. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1b34
Structure name
crystal structure of the d1d2 sub-complex from the human snrnp core domain
Structure deposition date
1998-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
52
Peptide accession
P62316
Residue number A
46
Residue number B
63
Peptide name
Small nuclear ribonucleoprotein Sm D2

Ligandability

Cysteine 46 of Small nuclear ribonucleoprotein Sm D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 63 of Small nuclear ribonucleoprotein Sm D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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