DNA-directed RNA polymerases I, II, and III subunit RPABC5
Intermolecular
Cysteine 236 of DNA-directed RNA polymerase II subunit RPB3 and cysteine 10
Cysteine 236 of DNA-directed RNA polymerase II subunit RPB3 and cysteine 7
Cysteine 10 and cysteine 924 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 45
Cysteine 919 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 10
Cysteine 236 of DNA-directed RNA polymerase II subunit RPB3 and cysteine 45
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 7
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 44
Cysteine 958 of DNA-directed RNA polymerase II subunit RPB2 and cysteine 44
Cysteine 919 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 44
More...Intramolecular
Cysteine 7 and cysteine 45
Cysteine 7 and cysteine 44
Cysteine 10 and cysteine 45
Cysteine 7 and cysteine 10
Cysteine 44 and cysteine 45
Cysteine 10 and cysteine 44
6xre C 236 J 10
A redox-regulated disulphide may form between cysteine 236 of DNA-directed RNA polymerase II subunit RPB3 and cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5.
Details
Redox score ?
74
PDB code
6xre
Structure name
structure of the p53/rna polymerase ii assembly
Structure deposition date
2020-07-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
80
Minimum pKa ?
2
% buried
100
Peptide A name
DNA-directed RNA polymerase II subunit RPB3
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
P19387
Peptide B accession
P62875
Peptide A residue number
236
Peptide B residue number
10
Ligandability
Cysteine 236 of DNA-directed RNA polymerase II subunit RPB3
Cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
6xre C 236 J 7
A redox-regulated disulphide may form between cysteine 236 of DNA-directed RNA polymerase II subunit RPB3 and cysteine 7 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6xre
Structure name
structure of the p53/rna polymerase ii assembly
Structure deposition date
2020-07-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
6
% buried
100
Peptide A name
DNA-directed RNA polymerase II subunit RPB3
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
P19387
Peptide B accession
P62875
Peptide A residue number
236
Peptide B residue number
7
Ligandability
Cysteine 236 of DNA-directed RNA polymerase II subunit RPB3
Cysteine 7 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7ast B 10 M 924
A redox-regulated disulphide may form between cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5 and cysteine 924 of DNA-directed RNA polymerase III subunit RPC2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
98
Minimum pKa ?
6
% buried
100
Peptide A name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide B name
DNA-directed RNA polymerase III subunit RPC2
Peptide A accession
P62875
Peptide B accession
Q9NW08
Peptide A residue number
10
Peptide B residue number
924
Ligandability
Cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2
7du2 B 924 J 45
A redox-regulated disulphide may form between cysteine 924 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 45 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7du2
Structure name
rna polymerase iii ec complex in post-translocation state
Structure deposition date
2021-01-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
92
Minimum pKa ?
3
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
Q9NW08
Peptide B accession
P62875
Peptide A residue number
924
Peptide B residue number
45
Ligandability
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 45 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7dn3 B 919 J 10
A redox-regulated disulphide may form between cysteine 919 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7dn3
Structure name
structure of human rna polymerase iii elongation complex
Structure deposition date
2020-12-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
95
Minimum pKa ?
11
% buried
nan
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
Q9NW08
Peptide B accession
P62875
Peptide A residue number
919
Peptide B residue number
10
Ligandability
Cysteine 919 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
6xre C 236 J 45
A redox-regulated disulphide may form between cysteine 236 of DNA-directed RNA polymerase II subunit RPB3 and cysteine 45 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6xre
Structure name
structure of the p53/rna polymerase ii assembly
Structure deposition date
2020-07-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide A name
DNA-directed RNA polymerase II subunit RPB3
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
P19387
Peptide B accession
P62875
Peptide A residue number
236
Peptide B residue number
45
Ligandability
Cysteine 236 of DNA-directed RNA polymerase II subunit RPB3
Cysteine 45 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7fjj B 924 J 7
A redox-regulated disulphide may form between cysteine 924 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 7 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7fjj
Structure name
human pol iii pre-termination complex
Structure deposition date
2021-08-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
nan
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
Q9NW08
Peptide B accession
P62875
Peptide A residue number
924
Peptide B residue number
7
Ligandability
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 7 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7aea B 924 J 44
A redox-regulated disulphide may form between cysteine 924 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7aea
Structure name
cryo-em structure of human rna polymerase iii elongation complex 2
Structure deposition date
2020-09-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
11
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
Q9NW08
Peptide B accession
P62875
Peptide A residue number
924
Peptide B residue number
44
Ligandability
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
5iy8 B 958 J 44
A redox-regulated disulphide may form between cysteine 958 of DNA-directed RNA polymerase II subunit RPB2 and cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
5iy8
Structure name
human holo-pic in the initial transcribing state
Structure deposition date
2016-03-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
94
Peptide A name
DNA-directed RNA polymerase II subunit RPB2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
P30876
Peptide B accession
P62875
Peptide A residue number
958
Peptide B residue number
44
Ligandability
Cysteine 958 of DNA-directed RNA polymerase II subunit RPB2
Cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7ae3 B 919 J 44
A redox-regulated disulphide may form between cysteine 919 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
22
PDB code
7ae3
Structure name
cryo-em structure of human rna polymerase iii elongation complex 3
Structure deposition date
2020-09-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
14
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
Q9NW08
Peptide B accession
P62875
Peptide A residue number
919
Peptide B residue number
44
Ligandability
Cysteine 919 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
5oik J 7 J 45
A redox-regulated disulphide may form within DNA-directed RNA polymerases I, II, and III subunit RPABC5 between cysteines 7 and 45.
Details
Redox score ?
75
PDB code
5oik
Structure name
structure of an rna polymerase ii-dsif transcription elongation complex
Structure deposition date
2017-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
4
% buried
100
Peptide accession
Q32P78
Residue number A
7
Residue number B
45
Peptide name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Ligandability
Cysteine 7 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 45 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7du2 J 7 J 44
A redox-regulated disulphide may form within DNA-directed RNA polymerases I, II, and III subunit RPABC5 between cysteines 7 and 44.
Details
Redox score ?
73
PDB code
7du2
Structure name
rna polymerase iii ec complex in post-translocation state
Structure deposition date
2021-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
6
% buried
100
Peptide accession
P62875
Residue number A
7
Residue number B
44
Peptide name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Ligandability
Cysteine 7 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
5iy6 J 10 J 45
A redox-regulated disulphide may form within DNA-directed RNA polymerases I, II, and III subunit RPABC5 between cysteines 10 and 45. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
5iy6
Structure name
human holo-pic in the closed state
Structure deposition date
2016-03-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
83
Minimum pKa ?
15
% buried
100
Peptide accession
P62875
Residue number A
10
Residue number B
45
Peptide name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Ligandability
Cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 45 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
5flm J 7 J 10
A redox-regulated disulphide may form within DNA-directed RNA polymerases I, II, and III subunit RPABC5 between cysteines 7 and 10. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
5flm
Structure name
structure of transcribing mammalian rna polymerase ii
Structure deposition date
2015-10-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
96
Minimum pKa ?
14
% buried
nan
Peptide accession
Q32P78
Residue number A
7
Residue number B
10
Peptide name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Ligandability
Cysteine 7 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
5iyb J 44 J 45
A redox-regulated disulphide may form within DNA-directed RNA polymerases I, II, and III subunit RPABC5 between cysteines 44 and 45. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
5iyb
Structure name
human core-pic in the open state
Structure deposition date
2016-03-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
86
Minimum pKa ?
16
% buried
100
Peptide accession
P62875
Residue number A
44
Residue number B
45
Peptide name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Ligandability
Cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 45 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
5flm J 10 J 44
A redox-regulated disulphide may form within DNA-directed RNA polymerases I, II, and III subunit RPABC5 between cysteines 10 and 44. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
5flm
Structure name
structure of transcribing mammalian rna polymerase ii
Structure deposition date
2015-10-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
95
Minimum pKa ?
23
% buried
nan
Peptide accession
Q32P78
Residue number A
10
Residue number B
44
Peptide name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Ligandability
Cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
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