ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

60S ribosomal protein L8

Intermolecular
Cysteine 300 of Ribosomal oxygenase 1 and cysteine 220
Cysteine 150 of Ribosomal oxygenase 1 and cysteine 220
A redox-regulated disulphide may form between cysteine 300 of Ribosomal oxygenase 1 and cysteine 220 of 60S ribosomal protein L8.

Details

Redox score ?
81
PDB code
4ccm
Structure name
60s ribosomal protein l8 histidine hydroxylase (no66) in complex with mn(ii), n-oxalylglycine (nog) and 60s ribosomal protein l8 (rpl8 g220c) peptide fragment (complex-1)
Structure deposition date
2013-10-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Ribosomal oxygenase 1
Peptide B name
60S ribosomal protein L8
Peptide A accession
Q9H6W3
Peptide B accession
P62917
Peptide A residue number
300
Peptide B residue number
220

Ligandability

Cysteine 300 of Ribosomal oxygenase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of 60S ribosomal protein L8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form between cysteine 150 of Ribosomal oxygenase 1 and cysteine 220 of 60S ribosomal protein L8 (299 and 220 respectively in this structure).

Details

Redox score ?
nan
PDB code
4ccn
Structure name
60s ribosomal protein l8 histidine hydroxylase (no66 l299c/c300s) in complex with mn(ii), n-oxalylglycine (nog) and 60s ribosomal protein l8 (rpl8 g220c) peptide fragment (complex-2)
Structure deposition date
2013-10-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide A name
Ribosomal oxygenase 1
Peptide B name
60S ribosomal protein L8
Peptide A accession
Q9H6W3
Peptide B accession
P62917
Peptide A residue number
150
Peptide B residue number
220

Ligandability

Cysteine 150 of Ribosomal oxygenase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of 60S ribosomal protein L8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 in protein B could not be asigned to a Uniprot residue.
If this tool was useful for finding a disulphide, please cite: