Ubiquitin-40S ribosomal protein S27a
Intramolecular
Cysteine 121 and cysteine 141
Cysteine 141 and cysteine 144
Cysteine 126 and cysteine 141
Cysteine 121 and cysteine 144
Cysteine 126 and cysteine 144
Cysteine 141 and cysteine 145
Cysteine 144 and cysteine 145
Cysteine 121 and cysteine 126
Cysteine 121 and cysteine 145
Cysteine 126 and cysteine 145
7wtt f 121 f 141
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 121 and 141.
Details
Redox score ?
99
PDB code
7wtt
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- a1 (with ck1)
Structure deposition date
2022-02-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
53
Minimum pKa ?
0
% buried
55
Peptide accession
P62979
Residue number A
121
Residue number B
141
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 121 of Ubiquitin-40S ribosomal protein S27a
Cysteine 141 of Ubiquitin-40S ribosomal protein S27a
7tql g 141 g 144
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 141 and 144.
Details
Redox score ?
86
PDB code
7tql
Structure name
cryoem structure of the human 40s small ribosomal subunit in complex with translation initiation factors eif1a and eif5b
Structure deposition date
2022-01-26
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
40
Peptide accession
P62979
Residue number A
141
Residue number B
144
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 141 of Ubiquitin-40S ribosomal protein S27a
Cysteine 144 of Ubiquitin-40S ribosomal protein S27a
5flx f 126 f 141
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 126 and 141.
Details
Redox score ?
79
PDB code
5flx
Structure name
mammalian 40s hcv-ires complex
Structure deposition date
2015-10-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P62979
Residue number A
126
Residue number B
141
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 126 of Ubiquitin-40S ribosomal protein S27a
Cysteine 141 of Ubiquitin-40S ribosomal protein S27a
6g18 f 121 f 144
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 121 and 144.
Details
Redox score ?
78
PDB code
6g18
Structure name
cryo-em structure of a late human pre-40s ribosomal subunit - state c
Structure deposition date
2018-03-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
54
Peptide accession
P62979
Residue number A
121
Residue number B
144
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 121 of Ubiquitin-40S ribosomal protein S27a
Cysteine 144 of Ubiquitin-40S ribosomal protein S27a
7wu0 f 126 f 144
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 126 and 144.
Details
Redox score ?
70
PDB code
7wu0
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b3
Structure deposition date
2022-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
11
% buried
60
Peptide accession
P62979
Residue number A
126
Residue number B
144
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 126 of Ubiquitin-40S ribosomal protein S27a
Cysteine 144 of Ubiquitin-40S ribosomal protein S27a
7wtt f 141 f 145
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 141 and 145.
Details
Redox score ?
65
PDB code
7wtt
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- a1 (with ck1)
Structure deposition date
2022-02-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
51
Minimum pKa ?
0
% buried
86
Peptide accession
P62979
Residue number A
141
Residue number B
145
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 141 of Ubiquitin-40S ribosomal protein S27a
Cysteine 145 of Ubiquitin-40S ribosomal protein S27a
7wtz f 144 f 145
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 144 and 145.
Details
Redox score ?
62
PDB code
7wtz
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b2
Structure deposition date
2022-02-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
82
Peptide accession
P62979
Residue number A
144
Residue number B
145
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 144 of Ubiquitin-40S ribosomal protein S27a
Cysteine 145 of Ubiquitin-40S ribosomal protein S27a
7wtw f 121 f 126
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 121 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7wtw
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- a3
Structure deposition date
2022-02-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
26
Peptide accession
P62979
Residue number A
121
Residue number B
126
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 121 of Ubiquitin-40S ribosomal protein S27a
Cysteine 126 of Ubiquitin-40S ribosomal protein S27a
7wtx f 121 f 145
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 121 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7wtx
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b1
Structure deposition date
2022-02-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
64
Peptide accession
P62979
Residue number A
121
Residue number B
145
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 121 of Ubiquitin-40S ribosomal protein S27a
Cysteine 145 of Ubiquitin-40S ribosomal protein S27a
7wtv f 126 f 145
A redox-regulated disulphide may form within Ubiquitin-40S ribosomal protein S27a between cysteines 126 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7wtv
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- a2
Structure deposition date
2022-02-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
74
Peptide accession
P62979
Residue number A
126
Residue number B
145
Peptide name
Ubiquitin-40S ribosomal protein S27a
Ligandability
Cysteine 126 of Ubiquitin-40S ribosomal protein S27a
Cysteine 145 of Ubiquitin-40S ribosomal protein S27a
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