Ras-related C3 botulinum toxin substrate 1
Intermolecular
Cysteine 250 of Secreted effector protein SptP and cysteine 18
Intramolecular
Cysteine 18 and cysteine 160
Cysteine 74 and cysteine 105
Cysteine 81 and cysteine 157
Cysteine 157 and cysteine 160
Cysteine 6 and cysteine 81
Cysteine 18 and cysteine 157
Cysteine 18 and cysteine 81
Cysteine 18 and cysteine 31
1g4u S 250 R 18
A redox-regulated disulphide may form between cysteine 250 of Secreted effector protein SptP and cysteine 18 of Ras-related C3 botulinum toxin substrate 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
1g4u
Structure name
crystal structure of the salmonella tyrosine phosphatase and gtpase activating protein sptp bound to rac1
Structure deposition date
2000-10-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
94
Peptide A name
Secreted effector protein SptP
Peptide B name
Ras-related C3 botulinum toxin substrate 1
Peptide A accession
P74873
Peptide B accession
P63000
Peptide A residue number
250
Peptide B residue number
18
Ligandability
Cysteine 250 of Secreted effector protein SptP
Cysteine 18 of Ras-related C3 botulinum toxin substrate 1
6agp A 18 A 160
A redox-regulated disulphide may form within Ras-related C3 botulinum toxin substrate 1 between cysteines 18 and 160. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6agp
Structure name
structure of rac1 in the low-affinity state for mg2+
Structure deposition date
2018-08-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
30
Peptide accession
P63000
Residue number A
18
Residue number B
160
Peptide name
Ras-related C3 botulinum toxin substrate 1
Ligandability
Cysteine 18 of Ras-related C3 botulinum toxin substrate 1
Cysteine 160 of Ras-related C3 botulinum toxin substrate 1
Cysteine 160 in protein B could not be asigned to a Uniprot residue.
6agp A 74 A 105
A redox-regulated disulphide may form within Ras-related C3 botulinum toxin substrate 1 between cysteines 74 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6agp
Structure name
structure of rac1 in the low-affinity state for mg2+
Structure deposition date
2018-08-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
12
Peptide accession
P63000
Residue number A
74
Residue number B
105
Peptide name
Ras-related C3 botulinum toxin substrate 1
Ligandability
Cysteine 74 of Ras-related C3 botulinum toxin substrate 1
Cysteine 105 of Ras-related C3 botulinum toxin substrate 1
Cysteine 74 in protein A could not be asigned to a Uniprot residue.
1mh1 A 81 A 157
A redox-regulated disulphide may form within Ras-related C3 botulinum toxin substrate 1 between cysteines 81 and 157. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
1mh1
Structure name
small g-protein
Structure deposition date
1997-01-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
P63000
Residue number A
81
Residue number B
157
Peptide name
Ras-related C3 botulinum toxin substrate 1
Ligandability
Cysteine 81 of Ras-related C3 botulinum toxin substrate 1
Cysteine 157 of Ras-related C3 botulinum toxin substrate 1
6agp A 157 A 160
A redox-regulated disulphide may form within Ras-related C3 botulinum toxin substrate 1 between cysteines 157 and 160. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6agp
Structure name
structure of rac1 in the low-affinity state for mg2+
Structure deposition date
2018-08-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
59
Peptide accession
P63000
Residue number A
157
Residue number B
160
Peptide name
Ras-related C3 botulinum toxin substrate 1
Ligandability
Cysteine 157 of Ras-related C3 botulinum toxin substrate 1
Cysteine 160 of Ras-related C3 botulinum toxin substrate 1
Cysteine 160 in protein B could not be asigned to a Uniprot residue.
3su8 A 6 A 81
A redox-regulated disulphide may form within Ras-related C3 botulinum toxin substrate 1 between cysteines 6 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
3su8
Structure name
crystal structure of a truncated intracellular domain of plexin-b1 in complex with rac1
Structure deposition date
2011-07-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
P63000
Residue number A
6
Residue number B
81
Peptide name
Ras-related C3 botulinum toxin substrate 1
Ligandability
Cysteine 6 of Ras-related C3 botulinum toxin substrate 1
Cysteine 81 of Ras-related C3 botulinum toxin substrate 1
5fi0 D 18 D 157
A redox-regulated disulphide may form within Ras-related C3 botulinum toxin substrate 1 between cysteines 18 and 157. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
5fi0
Structure name
crystal structure of the p-rex1 dh/ph tandem in complex with rac1
Structure deposition date
2015-12-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
80
Peptide accession
P63000
Residue number A
18
Residue number B
157
Peptide name
Ras-related C3 botulinum toxin substrate 1
Ligandability
Cysteine 18 of Ras-related C3 botulinum toxin substrate 1
Cysteine 157 of Ras-related C3 botulinum toxin substrate 1
2rmk A 18 A 81
A redox-regulated disulphide may form within Ras-related C3 botulinum toxin substrate 1 between cysteines 18 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
2rmk
Structure name
rac1/prk1 complex
Structure deposition date
2007-10-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
78
Peptide accession
P63000
Residue number A
18
Residue number B
81
Peptide name
Ras-related C3 botulinum toxin substrate 1
Ligandability
Cysteine 18 of Ras-related C3 botulinum toxin substrate 1
Cysteine 81 of Ras-related C3 botulinum toxin substrate 1
6agp A 18 A 31
A redox-regulated disulphide may form within Ras-related C3 botulinum toxin substrate 1 between cysteines 18 and 31.
Details
Redox score ?
nan
PDB code
6agp
Structure name
structure of rac1 in the low-affinity state for mg2+
Structure deposition date
2018-08-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
18
Peptide accession
P63000
Residue number A
18
Residue number B
31
Peptide name
Ras-related C3 botulinum toxin substrate 1
Ligandability
Cysteine 18 of Ras-related C3 botulinum toxin substrate 1
Cysteine 31 of Ras-related C3 botulinum toxin substrate 1
Cysteine 31 in protein B could not be asigned to a Uniprot residue.
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