a tool for identifying drug-targetable redox-active disulphides

Ubiquitin-conjugating enzyme E2 2

Intermolecular

Cysteine 48 of Polyubiquitin-B and cysteine 88

A redox-regulated disulphide may form between cysteine 48 of Polyubiquitin-B and cysteine 88 of Ubiquitin-conjugating enzyme E2 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

56

PDB code

Structure name

structure of yeast ubr1 in complex with ubc2 and monoubiquitinated n- degron

Structure deposition date

2021-04-08

Thiol separation (Å)

6

Half-sphere exposure sum ?

63

Minimum pK_a ?

10

% buried

nan

Peptide A name

Polyubiquitin-B

Peptide B name

Ubiquitin-conjugating enzyme E2 2

Peptide A accession

Peptide B accession

Peptide A residue number

48

Peptide B residue number

88

Ligandability

Cysteine 48 of Polyubiquitin-B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Ubiquitin-conjugating enzyme E2 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 48 in protein A could not be asigned to a Uniprot residue.

If this tool was useful for finding a disulphide, please cite: