ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Intramolecular
Cysteine 254 and cysteine 262
Cysteine 348 and cysteine 349
A redox-regulated disulphide may form within Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform between cysteines 254 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
3dw8
Structure name
structure of a protein phosphatase 2a holoenzyme with b55 subunit
Structure deposition date
2008-07-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
82
Peptide accession
P63151
Residue number A
254
Residue number B
262
Peptide name
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Ligandability

Cysteine 254 of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform between cysteines 348 and 349. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3dw8
Structure name
structure of a protein phosphatase 2a holoenzyme with b55 subunit
Structure deposition date
2008-07-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
11
% buried
100
Peptide accession
P63151
Residue number A
348
Residue number B
349
Peptide name
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Ligandability

Cysteine 348 of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 349 of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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