ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dynein light chain 1, cytoplasmic

Intramolecular
Cysteine 2 and cysteine 24
Cysteine 24 and cysteine 56
A redox-regulated disulphide may form within Dynein light chain 1, cytoplasmic between cysteines 2 and 24. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1f96
Structure name
solution structure of dynein light chain 8 (dlc8) and nnos peptide complex
Structure deposition date
2000-07-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
30
Peptide accession
P63170
Residue number A
2
Residue number B
24
Peptide name
Dynein light chain 1, cytoplasmic

Ligandability

Cysteine 2 of Dynein light chain 1, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 24 of Dynein light chain 1, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dynein light chain 1, cytoplasmic between cysteines 24 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1f95
Structure name
solution structure of dynein light chain 8 (dlc8) and bim peptide complex
Structure deposition date
2000-07-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
89
Peptide accession
P63170
Residue number A
24
Residue number B
56
Peptide name
Dynein light chain 1, cytoplasmic

Ligandability

Cysteine 24 of Dynein light chain 1, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of Dynein light chain 1, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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