S-phase kinase-associated protein 1
Intermolecular
Cysteine 160 and cysteine 342 of F-box/LRR-repeat protein 17 L
Cysteine 145 of F-box/WD repeat-containing protein 11 and cysteine 160 L
Cysteine 226 of F-box/LRR-repeat protein 5 and cysteine 160 L
Cysteine 33 of F-box/LRR-repeat protein 2 and cysteine 160 L
Cysteine 111 of S-phase kinase-associated protein 2 and cysteine 120 L
Cysteine 113 of S-phase kinase-associated protein 2 and cysteine 160 L
Cysteine 160 and cysteine 80 of F-box only protein 4 L
Cysteine 139 of F-box/WD repeat-containing protein 8 and cysteine 160 L
6w66 A 160 B 342
A redox-regulated disulphide may form between cysteine 160 of S-phase kinase-associated protein 1 and cysteine 342 of F-box/LRR-repeat protein 17.
Details
Redox score ?
79
PDB code
6w66
Structure name
the structure of the f64a, s172a mutant keap1-btb domain in complex with skp1-fbxl17
Structure deposition date
2020-03-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
7
% buried
61
Peptide A name
S-phase kinase-associated protein 1
Peptide B name
F-box/LRR-repeat protein 17
Peptide A accession
P63208
Peptide B accession
Q9UF56
Peptide A residue number
160
Peptide B residue number
342
Ligandability
Cysteine 160 of S-phase kinase-associated protein 1
Cysteine 342 of F-box/LRR-repeat protein 17
6wnx G 32 H 142
A redox-regulated disulphide may form between cysteine 145 of F-box/WD repeat-containing protein 11 and cysteine 160 of S-phase kinase-associated protein 1 (32 and 142 respectively in this structure).
Details
Redox score ?
75
PDB code
6wnx
Structure name
fbxw11-skp1 in complex with a pser33/pser37 beta-catenin peptide
Structure deposition date
2020-04-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
67
Peptide A name
F-box/WD repeat-containing protein 11
Peptide B name
S-phase kinase-associated protein 1
Peptide A accession
Q9UKB1
Peptide B accession
P63208
Peptide A residue number
145
Peptide B residue number
160
Ligandability
Cysteine 145 of F-box/WD repeat-containing protein 11
Cysteine 160 of S-phase kinase-associated protein 1
6vcd B 226 C 160
A redox-regulated disulphide may form between cysteine 226 of F-box/LRR-repeat protein 5 and cysteine 160 of S-phase kinase-associated protein 1.
Details
Redox score ?
73
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
7
% buried
86
Peptide A name
F-box/LRR-repeat protein 5
Peptide B name
S-phase kinase-associated protein 1
Peptide A accession
Q9UKA1
Peptide B accession
P63208
Peptide A residue number
226
Peptide B residue number
160
Ligandability
Cysteine 226 of F-box/LRR-repeat protein 5
Cysteine 160 of S-phase kinase-associated protein 1
6o60 C 33 D 160
A redox-regulated disulphide may form between cysteine 33 of F-box/LRR-repeat protein 2 and cysteine 160 of S-phase kinase-associated protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6o60
Structure name
crystal structure of ggtase3-fbxl2-skp1 complex
Structure deposition date
2019-03-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
56
Peptide A name
F-box/LRR-repeat protein 2
Peptide B name
S-phase kinase-associated protein 1
Peptide A accession
Q9UKC9
Peptide B accession
P63208
Peptide A residue number
33
Peptide B residue number
160
Ligandability
Cysteine 33 of F-box/LRR-repeat protein 2
Cysteine 160 of S-phase kinase-associated protein 1
1fqv A 123 B 120
A redox-regulated disulphide may form between cysteine 111 of S-phase kinase-associated protein 2 and cysteine 120 of S-phase kinase-associated protein 1 (123 and 120 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
1fqv
Structure name
insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex
Structure deposition date
2000-09-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
72
Peptide A name
S-phase kinase-associated protein 2
Peptide B name
S-phase kinase-associated protein 1
Peptide A accession
Q13309
Peptide B accession
P63208
Peptide A residue number
111
Peptide B residue number
120
Ligandability
Cysteine 111 of S-phase kinase-associated protein 2
Cysteine 120 of S-phase kinase-associated protein 1
1fqv M 125 N 160
A redox-regulated disulphide may form between cysteine 113 of S-phase kinase-associated protein 2 and cysteine 160 of S-phase kinase-associated protein 1 (125 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
1fqv
Structure name
insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex
Structure deposition date
2000-09-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
42
Peptide A name
S-phase kinase-associated protein 2
Peptide B name
S-phase kinase-associated protein 1
Peptide A accession
Q13309
Peptide B accession
P63208
Peptide A residue number
113
Peptide B residue number
160
Ligandability
Cysteine 113 of S-phase kinase-associated protein 2
Cysteine 160 of S-phase kinase-associated protein 1
3l2o A 1160 B 80
A redox-regulated disulphide may form between cysteine 160 of S-phase kinase-associated protein 1 and cysteine 80 of F-box only protein 4 (1160 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
3l2o
Structure name
structure-based mechanism of dimerization-dependent ubiquitination by the scffbx4 ubiquitin ligase
Structure deposition date
2009-12-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
34
Peptide A name
S-phase kinase-associated protein 1
Peptide B name
F-box only protein 4
Peptide A accession
P63208
Peptide B accession
Q9UKT5
Peptide A residue number
160
Peptide B residue number
80
Ligandability
Cysteine 160 of S-phase kinase-associated protein 1
Cysteine 80 of F-box only protein 4
7z8b F 139 S 160
A redox-regulated disulphide may form between cysteine 139 of F-box/WD repeat-containing protein 8 and cysteine 160 of S-phase kinase-associated protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7z8b
Structure name
structure of crl7fbxw8 reveals coupling with cul1-rbx1/roc1 for multi- cullin-ring e3-catalyzed ubiquitin ligation
Structure deposition date
2022-03-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
64
Peptide A name
F-box/WD repeat-containing protein 8
Peptide B name
S-phase kinase-associated protein 1
Peptide A accession
Q8N3Y1
Peptide B accession
P63208
Peptide A residue number
139
Peptide B residue number
160
Ligandability
Cysteine 139 of F-box/WD repeat-containing protein 8
Cysteine 160 of S-phase kinase-associated protein 1
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