ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Guanine nucleotide-binding protein G(T) subunit gamma-T1

Intermolecular
Cysteine 25 of Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 and cysteine 36 L
Cysteine 25 of Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 and cysteine 37 L
Intramolecular
Cysteine 36 and cysteine 37
A redox-regulated disulphide may form between cysteine 25 of Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 and cysteine 36 of Guanine nucleotide-binding protein G(T) subunit gamma-T1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
1got
Structure name
heterotrimeric complex of a gt-alpha/gi-alpha chimera and the gt-beta-gamma subunits
Structure deposition date
1996-08-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
32
Peptide A name
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Peptide B name
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Peptide A accession
P62871
Peptide B accession
P02698
Peptide A residue number
25
Peptide B residue number
36

Ligandability

Cysteine 25 of Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Guanine nucleotide-binding protein G(T) subunit gamma-T1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 25 of Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 and cysteine 37 of Guanine nucleotide-binding protein G(T) subunit gamma-T1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6oy9
Structure name
structure of the rhodopsin-transducin complex
Structure deposition date
2019-05-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
38
Peptide A name
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Peptide B name
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Peptide A accession
P62871
Peptide B accession
P02698
Peptide A residue number
25
Peptide B residue number
37

Ligandability

Cysteine 25 of Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Guanine nucleotide-binding protein G(T) subunit gamma-T1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide-binding protein G(T) subunit gamma-T1 between cysteines 36 and 37. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7l0r
Structure name
structure of nts-ntsr1-gi complex in lipid nanodisc, noncanonical state, without ahd
Structure deposition date
2020-12-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
21
Peptide accession
P63211
Residue number A
36
Residue number B
37
Peptide name
Guanine nucleotide-binding protein G(T) subunit gamma-T1

Ligandability

Cysteine 36 of Guanine nucleotide-binding protein G(T) subunit gamma-T1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Guanine nucleotide-binding protein G(T) subunit gamma-T1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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