a tool for identifying drug-targetable redox-active disulphides

40S ribosomal protein S21

Intramolecular

Cysteine 17 and cysteine 56 L

A redox-regulated disulphide may form within 40S ribosomal protein S21 between cysteines 17 and 56.

Details

Redox score ?

70

PDB code

Structure name

cryo-em structure of a late human pre-40s ribosomal subunit - mature

Structure deposition date

2018-03-29

Thiol separation (Å)

4

Half-sphere exposure sum ?

84

Minimum pK_a ?

6

% buried

100

Peptide accession

Residue number A

17

Residue number B

56

Peptide name

40S ribosomal protein S21

Ligandability

Cysteine 17 of 40S ribosomal protein S21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of 40S ribosomal protein S21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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