ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Eukaryotic translation initiation factor 5A-1

Intermolecular
Cysteine 129 and cysteine 129
Intramolecular
Cysteine 22 and cysteine 73
A redox-regulated disulphide may form between two units of Eukaryotic translation initiation factor 5A-1 at cysteines 129 and 129.

Details

Redox score ?
87
PDB code
3cpf
Structure name
crystal structure of human eukaryotic translation initiation factor eif5a
Structure deposition date
2008-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide A name
Eukaryotic translation initiation factor 5A-1
Peptide B name
Eukaryotic translation initiation factor 5A-1
Peptide A accession
P63241
Peptide B accession
P63241
Peptide A residue number
129
Peptide B residue number
129

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 5A-1 between cysteines 22 and 73.

Details

Redox score ?
72
PDB code
5dlq
Structure name
crystal structure of rangtp-exportin 4-eif5a complex
Structure deposition date
2015-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
50
Peptide accession
P63241
Residue number A
22
Residue number B
73
Peptide name
Eukaryotic translation initiation factor 5A-1

Ligandability

Cysteine 22 of Eukaryotic translation initiation factor 5A-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 73 of Eukaryotic translation initiation factor 5A-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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