ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Inward rectifier potassium channel 2

Intermolecular
Cysteine 89 and cysteine 169
A redox-regulated disulphide may form between two units of Inward rectifier potassium channel 2 at cysteines 89 and 169. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7zdz
Structure name
cryo-em structure of the human inward-rectifier potassium 2
Structure deposition date
2022-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
61
Peptide A name
Inward rectifier potassium channel 2
Peptide B name
Inward rectifier potassium channel 2
Peptide A accession
P63252
Peptide B accession
P63252
Peptide A residue number
89
Peptide B residue number
169

Ligandability

Cysteine 89 of Inward rectifier potassium channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Inward rectifier potassium channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: