ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcription elongation factor SPT4

Intramolecular
Cysteine 33 and cysteine 36 L
Cysteine 19 and cysteine 36 L
Cysteine 16 and cysteine 36 L
Cysteine 19 and cysteine 33 L
Cysteine 16 and cysteine 33 L
Cysteine 16 and cysteine 19
Cysteine 16 and cysteine 52
Cysteine 33 and cysteine 52 L
Cysteine 36 and cysteine 52 L
Cysteine 19 and cysteine 52
A redox-regulated disulphide may form within Transcription elongation factor SPT4 between cysteines 33 and 36.

Details

Redox score ?
76
PDB code
3h7h
Structure name
crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273)
Structure deposition date
2009-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
6
% buried
91
Peptide accession
P63272
Residue number A
33
Residue number B
36
Peptide name
Transcription elongation factor SPT4

Ligandability

Cysteine 33 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT4 between cysteines 19 and 36.

Details

Redox score ?
76
PDB code
3h7h
Structure name
crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273)
Structure deposition date
2009-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
5
% buried
91
Peptide accession
P63272
Residue number A
19
Residue number B
36
Peptide name
Transcription elongation factor SPT4

Ligandability

Cysteine 19 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT4 between cysteines 16 and 36.

Details

Redox score ?
75
PDB code
3h7h
Structure name
crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273)
Structure deposition date
2009-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
5
% buried
91
Peptide accession
P63272
Residue number A
16
Residue number B
36
Peptide name
Transcription elongation factor SPT4

Ligandability

Cysteine 16 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT4 between cysteines 19 and 33.

Details

Redox score ?
75
PDB code
3h7h
Structure name
crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273)
Structure deposition date
2009-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
5
% buried
100
Peptide accession
P63272
Residue number A
19
Residue number B
33
Peptide name
Transcription elongation factor SPT4

Ligandability

Cysteine 19 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT4 between cysteines 16 and 33.

Details

Redox score ?
72
PDB code
3h7h
Structure name
crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273)
Structure deposition date
2009-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
89
Minimum pKa ?
5
% buried
100
Peptide accession
P63272
Residue number A
16
Residue number B
33
Peptide name
Transcription elongation factor SPT4

Ligandability

Cysteine 16 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT4 between cysteines 16 and 19.

Details

Redox score ?
71
PDB code
3h7h
Structure name
crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273)
Structure deposition date
2009-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
88
Minimum pKa ?
5
% buried
100
Peptide accession
P63272
Residue number A
16
Residue number B
19
Peptide name
Transcription elongation factor SPT4

Ligandability

Cysteine 16 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 19 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT4 between cysteines 16 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
3h7h
Structure name
crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273)
Structure deposition date
2009-04-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
5
% buried
82
Peptide accession
P63272
Residue number A
16
Residue number B
52
Peptide name
Transcription elongation factor SPT4

Ligandability

Cysteine 16 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT4 between cysteines 33 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3h7h
Structure name
crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273)
Structure deposition date
2009-04-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
6
% buried
82
Peptide accession
P63272
Residue number A
33
Residue number B
52
Peptide name
Transcription elongation factor SPT4

Ligandability

Cysteine 33 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT4 between cysteines 36 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3h7h
Structure name
crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273)
Structure deposition date
2009-04-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
73
Peptide accession
P63272
Residue number A
36
Residue number B
52
Peptide name
Transcription elongation factor SPT4

Ligandability

Cysteine 36 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT4 between cysteines 19 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
6ted
Structure name
structure of complete, activated transcription complex pol ii-dsif- paf-spt6 uncovers allosteric elongation activation by rtf1
Structure deposition date
2019-11-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
86
Peptide accession
P63272
Residue number A
19
Residue number B
52
Peptide name
Transcription elongation factor SPT4

Ligandability

Cysteine 19 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Transcription elongation factor SPT4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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