SUMO-conjugating enzyme UBC9

Intermolecular

Cysteine 138 and cysteine 575 of Ran GTPase-activating protein 1 L

Intramolecular

A redox-regulated disulphide may form between cysteine 138 of SUMO-conjugating enzyme UBC9 and cysteine 575 of Ran GTPase-activating protein 1.

Details

Redox score ?

PDB code

1kps

Structure name

structural basis for e2-mediated sumo conjugation revealed by a complex between ubiquitin conjugating enzyme ubc9 and rangap1

Structure deposition date

2002-01-02

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

SUMO-conjugating enzyme UBC9

Peptide B name

Ran GTPase-activating protein 1

Peptide A accession

P63279

Peptide B accession

P46061

Peptide A residue number

138

Peptide B residue number

575

Ligandability

Cysteine 138 of SUMO-conjugating enzyme UBC9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 575 of Ran GTPase-activating protein 1

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SUMO-conjugating enzyme UBC9 between cysteines 43 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

2uyz

Structure name

non-covalent complex between ubc9 and sumo1

Structure deposition date

2007-04-21

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

P63280

Residue number A

Residue number B

Peptide name

SUMO-conjugating enzyme UBC9

Ligandability

Cysteine 43 of SUMO-conjugating enzyme UBC9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of SUMO-conjugating enzyme UBC9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SUMO-conjugating enzyme UBC9 between cysteines 75 and 93. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?