ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Intramolecular
Cysteine 266 and cysteine 269
Cysteine 32 and cysteine 133
Cysteine 55 and cysteine 165
A redox-regulated disulphide may form within Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform between cysteines 266 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2iae
Structure name
crystal structure of a protein phosphatase 2a (pp2a) holoenzyme
Structure deposition date
2006-09-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
62
Peptide accession
P67775
Residue number A
266
Residue number B
269
Peptide name
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Ligandability

Cysteine 266 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform between cysteines 32 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
2nym
Structure name
crystal structure of protein phosphatase 2a (pp2a) with c-terminus truncated catalytic subunit
Structure deposition date
2006-11-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
100
Peptide accession
P67775
Residue number A
32
Residue number B
133
Peptide name
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Ligandability

Cysteine 32 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform between cysteines 55 and 165. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
22
PDB code
4i5n
Structure name
structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation
Structure deposition date
2012-11-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
99
Minimum pKa ?
12
% buried
100
Peptide accession
P67775
Residue number A
55
Residue number B
165
Peptide name
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Ligandability

Cysteine 55 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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