Casein kinase II subunit beta
Intermolecular
Cysteine 140 and cysteine 140
Intramolecular
Cysteine 114 and cysteine 140
Cysteine 109 and cysteine 114 L
Cysteine 109 and cysteine 140 L
Cysteine 114 and cysteine 137
Cysteine 137 and cysteine 140
Cysteine 109 and cysteine 137 L
Cysteine 14 and cysteine 23 L
1qf8 A 140 B 140
A redox-regulated disulphide may form between two units of Casein kinase II subunit beta at cysteines 140 and 140.
Details
Redox score ?
70
PDB code
1qf8
Structure name
truncated form of casein kinase ii beta subunit (2-182) from homo sapiens
Structure deposition date
1999-04-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
0
% buried
52
Peptide A name
Casein kinase II subunit beta
Peptide B name
Casein kinase II subunit beta
Peptide A accession
P67870
Peptide B accession
P67870
Peptide A residue number
140
Peptide B residue number
140
Ligandability
2r6m A 114 A 140
A redox-regulated disulphide may form within Casein kinase II subunit beta between cysteines 114 and 140.
Details
Redox score ?
87
PDB code
2r6m
Structure name
crystal structure of rat ck2-beta subunit
Structure deposition date
2007-09-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
14
Peptide accession
P67874
Residue number A
114
Residue number B
140
Peptide name
Casein kinase II subunit beta
Ligandability
Cysteine 114 of Casein kinase II subunit beta
Cysteine 140 of Casein kinase II subunit beta
1jwh D 109 D 114
A redox-regulated disulphide may form within Casein kinase II subunit beta between cysteines 109 and 114.
Details
Redox score ?
82
PDB code
1jwh
Structure name
crystal structure of human protein kinase ck2 holoenzyme
Structure deposition date
2001-09-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
6
% buried
75
Peptide accession
P67870
Residue number A
109
Residue number B
114
Peptide name
Casein kinase II subunit beta
Ligandability
Cysteine 109 of Casein kinase II subunit beta
Cysteine 114 of Casein kinase II subunit beta
2r6m B 109 B 140
A redox-regulated disulphide may form within Casein kinase II subunit beta between cysteines 109 and 140.
Details
Redox score ?
80
PDB code
2r6m
Structure name
crystal structure of rat ck2-beta subunit
Structure deposition date
2007-09-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
24
Peptide accession
P67874
Residue number A
109
Residue number B
140
Peptide name
Casein kinase II subunit beta
Ligandability
Cysteine 109 of Casein kinase II subunit beta
Cysteine 140 of Casein kinase II subunit beta
4md7 B 114 B 137
A redox-regulated disulphide may form within Casein kinase II subunit beta between cysteines 114 and 137.
Details
Redox score ?
66
PDB code
4md7
Structure name
crystal structure of full-length symmetric ck2 holoenzyme
Structure deposition date
2013-08-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
14
% buried
nan
Peptide accession
P67870
Residue number A
114
Residue number B
137
Peptide name
Casein kinase II subunit beta
Ligandability
Cysteine 114 of Casein kinase II subunit beta
Cysteine 137 of Casein kinase II subunit beta
4md8 C 137 C 140
A redox-regulated disulphide may form within Casein kinase II subunit beta between cysteines 137 and 140.
Details
Redox score ?
63
PDB code
4md8
Structure name
crystal structure of full-length symmetric ck2 holoenzyme with mutated alpha subunit (f121e)
Structure deposition date
2013-08-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
14
% buried
nan
Peptide accession
P67870
Residue number A
137
Residue number B
140
Peptide name
Casein kinase II subunit beta
Ligandability
Cysteine 137 of Casein kinase II subunit beta
Cysteine 140 of Casein kinase II subunit beta
4dgl B 109 B 137
A redox-regulated disulphide may form within Casein kinase II subunit beta between cysteines 109 and 137.
Details
Redox score ?
62
PDB code
4dgl
Structure name
crystal structure of the ck2 tetrameric holoenzyme
Structure deposition date
2012-01-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
14
% buried
84
Peptide accession
P67870
Residue number A
109
Residue number B
137
Peptide name
Casein kinase II subunit beta
Ligandability
Cysteine 109 of Casein kinase II subunit beta
Cysteine 137 of Casein kinase II subunit beta
2r6m B 14 B 23
A redox-regulated disulphide may form within Casein kinase II subunit beta between cysteines 14 and 23. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
2r6m
Structure name
crystal structure of rat ck2-beta subunit
Structure deposition date
2007-09-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
88
Peptide accession
P67874
Residue number A
14
Residue number B
23
Peptide name
Casein kinase II subunit beta
Ligandability
Cysteine 14 of Casein kinase II subunit beta
Cysteine 23 of Casein kinase II subunit beta
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