Ubiquitin-conjugating enzyme E2 L3

Intermolecular

Cysteine 357 of E3 ubiquitin-protein ligase ARIH1 and cysteine 86 L

A redox-regulated disulphide may form between cysteine 357 of E3 ubiquitin-protein ligase ARIH1 and cysteine 86 of Ubiquitin-conjugating enzyme E2 L3.

Details

Redox score ?

PDB code

7b5l

Structure name

ubiquitin ligation to f-box protein substrates by scf-rbr e3-e3 super- assembly: nedd8-cul1-rbx1-skp1-skp2-ckshs1-cyclin a-cdk2-p27- ube2l3~ub~arih1

Structure deposition date

2020-12-04

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

E3 ubiquitin-protein ligase ARIH1

Peptide B name

Ubiquitin-conjugating enzyme E2 L3

Peptide A accession

Q9Y4X5

Peptide B accession

P68036

Peptide A residue number

357

Peptide B residue number

Ligandability

Cysteine 357 of E3 ubiquitin-protein ligase ARIH1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 86 of Ubiquitin-conjugating enzyme E2 L3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: