ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Coxsackievirus and adenovirus receptor

Intramolecular
Cysteine 162 and cysteine 212
Cysteine 146 and cysteine 223
Cysteine 41 and cysteine 120
Cysteine 146 and cysteine 162
Cysteine 146 and cysteine 212
Cysteine 162 and cysteine 223
Cysteine 212 and cysteine 223
A redox-regulated disulphide may form within Coxsackievirus and adenovirus receptor between cysteines 162 and 212 (23 and 73 respectively in this structure).

Details

Redox score ?
84
PDB code
2npl
Structure name
nmr structure of card d2 domain
Structure deposition date
2006-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78310
Residue number A
162
Residue number B
212
Peptide name
Coxsackievirus and adenovirus receptor

Ligandability

Cysteine 162 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coxsackievirus and adenovirus receptor between cysteines 146 and 223 (7 and 84 respectively in this structure).

Details

Redox score ?
84
PDB code
2npl
Structure name
nmr structure of card d2 domain
Structure deposition date
2006-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78310
Residue number A
146
Residue number B
223
Peptide name
Coxsackievirus and adenovirus receptor

Ligandability

Cysteine 146 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coxsackievirus and adenovirus receptor between cysteines 41 and 120.

Details

Redox score ?
80
PDB code
2w9l
Structure name
canine adenovirus type 2 fibre head in complex with car domain d1 and sialic acid
Structure deposition date
2009-01-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78310
Residue number A
41
Residue number B
120
Peptide name
Coxsackievirus and adenovirus receptor

Ligandability

Cysteine 41 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coxsackievirus and adenovirus receptor between cysteines 146 and 162 (7 and 23 respectively in this structure).

Details

Redox score ?
75
PDB code
2npl
Structure name
nmr structure of card d2 domain
Structure deposition date
2006-10-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78310
Residue number A
146
Residue number B
162
Peptide name
Coxsackievirus and adenovirus receptor

Ligandability

Cysteine 146 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coxsackievirus and adenovirus receptor between cysteines 146 and 212 (7 and 73 respectively in this structure).

Details

Redox score ?
68
PDB code
2npl
Structure name
nmr structure of card d2 domain
Structure deposition date
2006-10-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78310
Residue number A
146
Residue number B
212
Peptide name
Coxsackievirus and adenovirus receptor

Ligandability

Cysteine 146 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coxsackievirus and adenovirus receptor between cysteines 162 and 223 (23 and 84 respectively in this structure).

Details

Redox score ?
67
PDB code
2npl
Structure name
nmr structure of card d2 domain
Structure deposition date
2006-10-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78310
Residue number A
162
Residue number B
223
Peptide name
Coxsackievirus and adenovirus receptor

Ligandability

Cysteine 162 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coxsackievirus and adenovirus receptor between cysteines 212 and 223 (73 and 84 respectively in this structure).

Details

Redox score ?
63
PDB code
2npl
Structure name
nmr structure of card d2 domain
Structure deposition date
2006-10-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78310
Residue number A
212
Residue number B
223
Peptide name
Coxsackievirus and adenovirus receptor

Ligandability

Cysteine 212 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of Coxsackievirus and adenovirus receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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