ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribonuclease P protein subunit p38

Intramolecular
Cysteine 135 and cysteine 176
Cysteine 135 and cysteine 159
A redox-regulated disulphide may form within Ribonuclease P protein subunit p38 between cysteines 135 and 176. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
36
Peptide accession
P78345
Residue number A
135
Residue number B
176
Peptide name
Ribonuclease P protein subunit p38

Ligandability

Cysteine 135 of Ribonuclease P protein subunit p38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 176 of Ribonuclease P protein subunit p38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease P protein subunit p38 between cysteines 135 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6ahu
Structure name
cryo-em structure of human ribonuclease p with mature trna
Structure deposition date
2018-08-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
69
Peptide accession
P78345
Residue number A
135
Residue number B
159
Peptide name
Ribonuclease P protein subunit p38

Ligandability

Cysteine 135 of Ribonuclease P protein subunit p38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Ribonuclease P protein subunit p38

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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