Acid-sensing ion channel 1
Intramolecular
Cysteine 323 and cysteine 345
Cysteine 172 and cysteine 179
Cysteine 314 and cysteine 361
Cysteine 325 and cysteine 337
Cysteine 290 and cysteine 367
Cysteine 310 and cysteine 363
Cysteine 93 and cysteine 194
Cysteine 361 and cysteine 363
Cysteine 323 and cysteine 325
Cysteine 323 and cysteine 337
More...Cysteine 310 and cysteine 361
Cysteine 314 and cysteine 363
Cysteine 325 and cysteine 345
Cysteine 337 and cysteine 345
Cysteine 310 and cysteine 314
Cysteine 59 and cysteine 61
6l6n A 323 A 345
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 323 and 345.
Details
Redox score ?
84
PDB code
6l6n
Structure name
hasic1a co-crystallized with nafamostat
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
323
Residue number B
345
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 323 of Acid-sensing ion channel 1
Cysteine 345 of Acid-sensing ion channel 1
6l6n A 172 A 179
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 172 and 179.
Details
Redox score ?
84
PDB code
6l6n
Structure name
hasic1a co-crystallized with nafamostat
Structure deposition date
2019-10-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
62
Peptide accession
P78348
Residue number A
172
Residue number B
179
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 172 of Acid-sensing ion channel 1
Cysteine 179 of Acid-sensing ion channel 1
6l6i B 314 B 361
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 314 and 361.
Details
Redox score ?
84
PDB code
6l6i
Structure name
hasic1a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
314
Residue number B
361
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 314 of Acid-sensing ion channel 1
Cysteine 361 of Acid-sensing ion channel 1
6l6i C 325 C 337
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 325 and 337.
Details
Redox score ?
83
PDB code
6l6i
Structure name
hasic1a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
325
Residue number B
337
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 325 of Acid-sensing ion channel 1
Cysteine 337 of Acid-sensing ion channel 1
6l6n C 290 C 367
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 290 and 367.
Details
Redox score ?
82
PDB code
6l6n
Structure name
hasic1a co-crystallized with nafamostat
Structure deposition date
2019-10-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
38
Peptide accession
P78348
Residue number A
290
Residue number B
367
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 290 of Acid-sensing ion channel 1
Cysteine 367 of Acid-sensing ion channel 1
6l6i B 310 B 363
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 310 and 363.
Details
Redox score ?
82
PDB code
6l6i
Structure name
hasic1a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
310
Residue number B
363
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 310 of Acid-sensing ion channel 1
Cysteine 363 of Acid-sensing ion channel 1
6l6i C 93 C 194
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 93 and 194.
Details
Redox score ?
80
PDB code
6l6i
Structure name
hasic1a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
93
Residue number B
194
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 93 of Acid-sensing ion channel 1
Cysteine 194 of Acid-sensing ion channel 1
6l6n C 361 C 363
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 361 and 363.
Details
Redox score ?
74
PDB code
6l6n
Structure name
hasic1a co-crystallized with nafamostat
Structure deposition date
2019-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
361
Residue number B
363
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 361 of Acid-sensing ion channel 1
Cysteine 363 of Acid-sensing ion channel 1
6l6n A 323 A 325
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 323 and 325.
Details
Redox score ?
65
PDB code
6l6n
Structure name
hasic1a co-crystallized with nafamostat
Structure deposition date
2019-10-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
323
Residue number B
325
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 323 of Acid-sensing ion channel 1
Cysteine 325 of Acid-sensing ion channel 1
6l6n B 323 B 337
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 323 and 337.
Details
Redox score ?
63
PDB code
6l6n
Structure name
hasic1a co-crystallized with nafamostat
Structure deposition date
2019-10-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
323
Residue number B
337
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 323 of Acid-sensing ion channel 1
Cysteine 337 of Acid-sensing ion channel 1
6l6i A 310 A 361
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 310 and 361.
Details
Redox score ?
62
PDB code
6l6i
Structure name
hasic1a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
310
Residue number B
361
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 310 of Acid-sensing ion channel 1
Cysteine 361 of Acid-sensing ion channel 1
6l6i A 314 A 363
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 314 and 363.
Details
Redox score ?
62
PDB code
6l6i
Structure name
hasic1a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
314
Residue number B
363
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 314 of Acid-sensing ion channel 1
Cysteine 363 of Acid-sensing ion channel 1
6l6i A 325 A 345
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 325 and 345. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
6l6i
Structure name
hasic1a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
325
Residue number B
345
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 325 of Acid-sensing ion channel 1
Cysteine 345 of Acid-sensing ion channel 1
6l6n C 337 C 345
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 337 and 345. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
6l6n
Structure name
hasic1a co-crystallized with nafamostat
Structure deposition date
2019-10-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
337
Residue number B
345
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 337 of Acid-sensing ion channel 1
Cysteine 345 of Acid-sensing ion channel 1
6l6i B 310 B 314
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 310 and 314. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6l6i
Structure name
hasic1a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78348
Residue number A
310
Residue number B
314
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 310 of Acid-sensing ion channel 1
Cysteine 314 of Acid-sensing ion channel 1
6l6n B 59 B 61
A redox-regulated disulphide may form within Acid-sensing ion channel 1 between cysteines 59 and 61. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6l6n
Structure name
hasic1a co-crystallized with nafamostat
Structure deposition date
2019-10-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
39
Minimum pKa ?
10
% buried
0
Peptide accession
P78348
Residue number A
59
Residue number B
61
Peptide name
Acid-sensing ion channel 1
Ligandability
Cysteine 59 of Acid-sensing ion channel 1
Cysteine 61 of Acid-sensing ion channel 1
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