ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Disks large homolog 4

Intramolecular
Cysteine 562 and cysteine 626
Cysteine 3 and cysteine 5
A redox-regulated disulphide may form within Disks large homolog 4 between cysteines 562 and 626.

Details

Redox score ?
68
PDB code
1jxm
Structure name
crystal structure of the gmp bound sh3-hook-gk fragment of psd-95
Structure deposition date
2001-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
94
Peptide accession
P31016
Residue number A
562
Residue number B
626
Peptide name
Disks large homolog 4

Ligandability

Cysteine 562 of Disks large homolog 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 626 of Disks large homolog 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Disks large homolog 4 between cysteines 3 and 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5j7j
Structure name
nmr derived structure of ca2+ calmodulin bound to phosphorylated psd- 95
Structure deposition date
2016-04-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
99
Peptide accession
P78352
Residue number A
3
Residue number B
5
Peptide name
Disks large homolog 4

Ligandability

Cysteine 3 of Disks large homolog 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 5 of Disks large homolog 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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