ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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SRSF protein kinase 2

Intramolecular
Cysteine 131 and cysteine 208
Cysteine 98 and cysteine 163
A redox-regulated disulphide may form within SRSF protein kinase 2 between cysteines 131 and 208 (142 and 219 respectively in this structure).

Details

Redox score ?
75
PDB code
5myv
Structure name
crystal structure of srpk2 in complex with compound 1
Structure deposition date
2017-01-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
62
Peptide accession
P78362
Residue number A
131
Residue number B
208
Peptide name
SRSF protein kinase 2

Ligandability

Cysteine 131 of SRSF protein kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of SRSF protein kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SRSF protein kinase 2 between cysteines 98 and 163 (109 and 174 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
5myv
Structure name
crystal structure of srpk2 in complex with compound 1
Structure deposition date
2017-01-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
85
Peptide accession
P78362
Residue number A
98
Residue number B
163
Peptide name
SRSF protein kinase 2

Ligandability

Cysteine 98 of SRSF protein kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of SRSF protein kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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