Oxidized low-density lipoprotein receptor 1
Intermolecular
Cysteine 140 and cysteine 140
Cysteine 144 and cysteine 144
Intramolecular
Cysteine 144 and cysteine 155
Cysteine 172 and cysteine 264
Cysteine 243 and cysteine 256
6tla A 140 B 140
A redox-regulated disulphide may form between two units of Oxidized low-density lipoprotein receptor 1 at cysteines 140 and 140.
Details
Redox score ?
90
PDB code
6tla
Structure name
crystal structure of lectin-like ox-ldl receptor 1 (c 1 2 1)
Structure deposition date
2019-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
26
Minimum pKa ?
nan
% buried
nan
Peptide A name
Oxidized low-density lipoprotein receptor 1
Peptide B name
Oxidized low-density lipoprotein receptor 1
Peptide A accession
P78380
Peptide B accession
P78380
Peptide A residue number
140
Peptide B residue number
140
Ligandability
1ypo G 144 H 144
A redox-regulated disulphide may form between two units of Oxidized low-density lipoprotein receptor 1 at cysteines 144 and 144. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1ypo
Structure name
human oxidized low density lipoprotein receptor lox-1 p3 1 21 space group
Structure deposition date
2005-01-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide A name
Oxidized low-density lipoprotein receptor 1
Peptide B name
Oxidized low-density lipoprotein receptor 1
Peptide A accession
P78380
Peptide B accession
P78380
Peptide A residue number
144
Peptide B residue number
144
Ligandability
6tla A 144 A 155
A redox-regulated disulphide may form within Oxidized low-density lipoprotein receptor 1 between cysteines 144 and 155.
Details
Redox score ?
83
PDB code
6tla
Structure name
crystal structure of lectin-like ox-ldl receptor 1 (c 1 2 1)
Structure deposition date
2019-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78380
Residue number A
144
Residue number B
155
Peptide name
Oxidized low-density lipoprotein receptor 1
Ligandability
Cysteine 144 of Oxidized low-density lipoprotein receptor 1
Cysteine 155 of Oxidized low-density lipoprotein receptor 1
3vlg A 172 A 264
A redox-regulated disulphide may form within Oxidized low-density lipoprotein receptor 1 between cysteines 172 and 264.
Details
Redox score ?
82
PDB code
3vlg
Structure name
crystal structure of the w150a mutant lox-1 ctld showing impaired oxldl binding
Structure deposition date
2011-12-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78380
Residue number A
172
Residue number B
264
Peptide name
Oxidized low-density lipoprotein receptor 1
Ligandability
Cysteine 172 of Oxidized low-density lipoprotein receptor 1
Cysteine 264 of Oxidized low-density lipoprotein receptor 1
6tl9 H 243 H 256
A redox-regulated disulphide may form within Oxidized low-density lipoprotein receptor 1 between cysteines 243 and 256.
Details
Redox score ?
82
PDB code
6tl9
Structure name
crystal structure of lectin-like ox-ldl receptor 1 in complex with bi- 0115
Structure deposition date
2019-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78380
Residue number A
243
Residue number B
256
Peptide name
Oxidized low-density lipoprotein receptor 1
Ligandability
Cysteine 243 of Oxidized low-density lipoprotein receptor 1
Cysteine 256 of Oxidized low-density lipoprotein receptor 1
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