ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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mRNA export factor RAE1

Intramolecular
Cysteine 173 and cysteine 175
Cysteine 175 and cysteine 217
Cysteine 321 and cysteine 322
Cysteine 217 and cysteine 321
Cysteine 217 and cysteine 259
Cysteine 44 and cysteine 322
Cysteine 44 and cysteine 93 L
Cysteine 44 and cysteine 106 L
A redox-regulated disulphide may form within mRNA export factor RAE1 between cysteines 173 and 175. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7f90
Structure name
crystal structure of sars auxiliary protein in complex with human nuclear protein
Structure deposition date
2021-07-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
93
Minimum pKa ?
11
% buried
100
Peptide accession
P78406
Residue number A
173
Residue number B
175
Peptide name
mRNA export factor RAE1

Ligandability

Cysteine 173 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA export factor RAE1 between cysteines 175 and 217. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7vpg
Structure name
crystal structure of the c-terminal tail of sars-cov-1 orf6 complex with human nucleoporin pair rae1-nup98
Structure deposition date
2021-10-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
94
Minimum pKa ?
13
% buried
100
Peptide accession
P78406
Residue number A
175
Residue number B
217
Peptide name
mRNA export factor RAE1

Ligandability

Cysteine 175 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA export factor RAE1 between cysteines 321 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7vph
Structure name
crystal structure of the c-terminal tail of sars-cov-2 orf6 complex with human nucleoporin pair rae1-nup98
Structure deposition date
2021-10-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
P78406
Residue number A
321
Residue number B
322
Peptide name
mRNA export factor RAE1

Ligandability

Cysteine 321 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA export factor RAE1 between cysteines 217 and 321. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
7vph
Structure name
crystal structure of the c-terminal tail of sars-cov-2 orf6 complex with human nucleoporin pair rae1-nup98
Structure deposition date
2021-10-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
95
Minimum pKa ?
13
% buried
100
Peptide accession
P78406
Residue number A
217
Residue number B
321
Peptide name
mRNA export factor RAE1

Ligandability

Cysteine 217 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 321 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA export factor RAE1 between cysteines 217 and 259. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
3mmy
Structure name
structural and functional analysis of the interaction between the nucleoporin nup98 and the mrna export factor rae1
Structure deposition date
2010-04-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
P78406
Residue number A
217
Residue number B
259
Peptide name
mRNA export factor RAE1

Ligandability

Cysteine 217 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 259 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA export factor RAE1 between cysteines 44 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
21
PDB code
7vph
Structure name
crystal structure of the c-terminal tail of sars-cov-2 orf6 complex with human nucleoporin pair rae1-nup98
Structure deposition date
2021-10-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
P78406
Residue number A
44
Residue number B
322
Peptide name
mRNA export factor RAE1

Ligandability

Cysteine 44 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA export factor RAE1 between cysteines 44 and 93. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
20
PDB code
7f60
Structure name
crystal structure of auxiliary protein in complex with human nuclear protein
Structure deposition date
2021-06-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
100
Peptide accession
P78406
Residue number A
44
Residue number B
93
Peptide name
mRNA export factor RAE1

Ligandability

Cysteine 44 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA export factor RAE1 between cysteines 44 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
19
PDB code
7f90
Structure name
crystal structure of sars auxiliary protein in complex with human nuclear protein
Structure deposition date
2021-07-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
100
Peptide accession
P78406
Residue number A
44
Residue number B
106
Peptide name
mRNA export factor RAE1

Ligandability

Cysteine 44 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of mRNA export factor RAE1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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