ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Butyrophilin subfamily 3 member A2

Intramolecular
Cysteine 166 and cysteine 220
Cysteine 52 and cysteine 126
A redox-regulated disulphide may form within Butyrophilin subfamily 3 member A2 between cysteines 166 and 220 (137 and 191 respectively in this structure).

Details

Redox score ?
81
PDB code
4f8q
Structure name
crystal structure of the human btn3a2 ectodomain
Structure deposition date
2012-05-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78410
Residue number A
166
Residue number B
220
Peptide name
Butyrophilin subfamily 3 member A2

Ligandability

Cysteine 166 of Butyrophilin subfamily 3 member A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Butyrophilin subfamily 3 member A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Butyrophilin subfamily 3 member A2 between cysteines 52 and 126 (23 and 97 respectively in this structure).

Details

Redox score ?
81
PDB code
4f8q
Structure name
crystal structure of the human btn3a2 ectodomain
Structure deposition date
2012-05-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78410
Residue number A
52
Residue number B
126
Peptide name
Butyrophilin subfamily 3 member A2

Ligandability

Cysteine 52 of Butyrophilin subfamily 3 member A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Butyrophilin subfamily 3 member A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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