ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glutathione S-transferase omega-1

Intramolecular
Cysteine 32 and cysteine 237 L
A redox-regulated disulphide may form within Glutathione S-transferase omega-1 between cysteines 32 and 237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6pnn
Structure name
human gsto1-1 complexed with 2-chloro-n-(4-chloro-3-(n-(2- methoxyethyl)-n-methylsulfamoyl)phenyl)acetamide
Structure deposition date
2019-07-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
88
Peptide accession
P78417
Residue number A
32
Residue number B
237
Peptide name
Glutathione S-transferase omega-1

Ligandability

Cysteine 32 of Glutathione S-transferase omega-1

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Glutathione S-transferase omega-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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