Fractalkine
Intermolecular
Cysteine 36 and cysteine 263 of G-protein coupled receptor homolog US28
Cysteine 36 and cysteine 32
Cysteine 74 and cysteine 263 of G-protein coupled receptor homolog US28
Intramolecular
Cysteine 32 and cysteine 58
Cysteine 36 and cysteine 74
Cysteine 32 and cysteine 74
Cysteine 36 and cysteine 58
Cysteine 58 and cysteine 74
7rkf L 12 R 263
A redox-regulated disulphide may form between cysteine 36 of Fractalkine and cysteine 263 of G-protein coupled receptor homolog US28 (12 and 263 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7rkf
Structure name
structure of cx3cl1-us28-g11in18-scfv16 in tl-state
Structure deposition date
2021-07-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide A name
Fractalkine
Peptide B name
G-protein coupled receptor homolog US28
Peptide A accession
P78423
Peptide B accession
P69332
Peptide A residue number
36
Peptide B residue number
263
Ligandability
Cysteine 36 of Fractalkine
Cysteine 263 of G-protein coupled receptor homolog US28
1f2l B 12 C 8
A redox-regulated disulphide may form between two units of Fractalkine at cysteines 36 and 32 (12 and 8 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
1f2l
Structure name
crystal structure of chemokine domain of fractalkine
Structure deposition date
2000-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide A name
Fractalkine
Peptide B name
Fractalkine
Peptide A accession
P78423
Peptide B accession
P78423
Peptide A residue number
36
Peptide B residue number
32
Ligandability
Cysteine 36 of Fractalkine
Cysteine 32 of Fractalkine
7rkm L 50 R 263
A redox-regulated disulphide may form between cysteine 74 of Fractalkine and cysteine 263 of G-protein coupled receptor homolog US28 (50 and 263 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7rkm
Structure name
structure of cx3cl1-us28-gi-scfv16 in c-state
Structure deposition date
2021-07-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
Fractalkine
Peptide B name
G-protein coupled receptor homolog US28
Peptide A accession
P78423
Peptide B accession
P69332
Peptide A residue number
74
Peptide B residue number
263
Ligandability
Cysteine 74 of Fractalkine
Cysteine 263 of G-protein coupled receptor homolog US28
1f2l B 8 B 34
A redox-regulated disulphide may form within Fractalkine between cysteines 32 and 58 (8 and 34 respectively in this structure).
Details
Redox score ?
88
PDB code
1f2l
Structure name
crystal structure of chemokine domain of fractalkine
Structure deposition date
2000-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78423
Residue number A
32
Residue number B
58
Peptide name
Fractalkine
Ligandability
Cysteine 32 of Fractalkine
Cysteine 58 of Fractalkine
1f2l A 12 A 50
A redox-regulated disulphide may form within Fractalkine between cysteines 36 and 74 (12 and 50 respectively in this structure).
Details
Redox score ?
82
PDB code
1f2l
Structure name
crystal structure of chemokine domain of fractalkine
Structure deposition date
2000-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78423
Residue number A
36
Residue number B
74
Peptide name
Fractalkine
Ligandability
Cysteine 36 of Fractalkine
Cysteine 74 of Fractalkine
1b2t A 8 A 50
A redox-regulated disulphide may form within Fractalkine between cysteines 32 and 74 (8 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
1b2t
Structure name
solution structure of the cx3c chemokine domain of fractalkine
Structure deposition date
1998-12-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78423
Residue number A
32
Residue number B
74
Peptide name
Fractalkine
Ligandability
Cysteine 32 of Fractalkine
Cysteine 74 of Fractalkine
1f2l D 12 D 34
A redox-regulated disulphide may form within Fractalkine between cysteines 36 and 58 (12 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
1f2l
Structure name
crystal structure of chemokine domain of fractalkine
Structure deposition date
2000-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78423
Residue number A
36
Residue number B
58
Peptide name
Fractalkine
Ligandability
Cysteine 36 of Fractalkine
Cysteine 58 of Fractalkine
1b2t A 34 A 50
A redox-regulated disulphide may form within Fractalkine between cysteines 58 and 74 (34 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
1b2t
Structure name
solution structure of the cx3c chemokine domain of fractalkine
Structure deposition date
1998-12-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78423
Residue number A
58
Residue number B
74
Peptide name
Fractalkine
Ligandability
Cysteine 58 of Fractalkine
Cysteine 74 of Fractalkine
If this tool was useful for finding a disulphide, please cite: