ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ETS-related transcription factor Elf-3

Intramolecular
Cysteine 95 and cysteine 105
Cysteine 103 and cysteine 105
A redox-regulated disulphide may form within ETS-related transcription factor Elf-3 between cysteines 95 and 105 (55 and 65 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2e8p
Structure name
solution structure of the n-terminal sam-domain of e74-like factor 3
Structure deposition date
2007-01-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
11
% buried
37
Peptide accession
Q6IAP8
Residue number A
95
Residue number B
105
Peptide name
ETS-related transcription factor Elf-3

Ligandability

Cysteine 95 of ETS-related transcription factor Elf-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of ETS-related transcription factor Elf-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ETS-related transcription factor Elf-3 between cysteines 103 and 105 (63 and 65 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2e8p
Structure name
solution structure of the n-terminal sam-domain of e74-like factor 3
Structure deposition date
2007-01-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
22
Peptide accession
Q6IAP8
Residue number A
103
Residue number B
105
Peptide name
ETS-related transcription factor Elf-3

Ligandability

Cysteine 103 of ETS-related transcription factor Elf-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of ETS-related transcription factor Elf-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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