C-C motif chemokine 20
Intermolecular
Cysteine 33 and cysteine 36 of C-C chemokine receptor type 6
Cysteine 32 and cysteine 36 of C-C chemokine receptor type 6
Cysteine 74 and cysteine 36 of C-C chemokine receptor type 6
Cysteine 33 and cysteine 288 of C-C chemokine receptor type 6
Intramolecular
Cysteine 32 and cysteine 58
Cysteine 33 and cysteine 74
Cysteine 33 and cysteine 58
Cysteine 32 and cysteine 33
Cysteine 32 and cysteine 74
Cysteine 58 and cysteine 74
6wwz C 7 R 36
A redox-regulated disulphide may form between cysteine 33 of C-C motif chemokine 20 and cysteine 36 of C-C chemokine receptor type 6 (7 and 36 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6wwz
Structure name
cryo-em structure of the human chemokine receptor ccr6 in complex with ccl20 and a go protein
Structure deposition date
2020-05-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 20
Peptide B name
C-C chemokine receptor type 6
Peptide A accession
P78556
Peptide B accession
P51684
Peptide A residue number
33
Peptide B residue number
36
Ligandability
Cysteine 33 of C-C motif chemokine 20
Cysteine 36 of C-C chemokine receptor type 6
6wwz C 6 R 36
A redox-regulated disulphide may form between cysteine 32 of C-C motif chemokine 20 and cysteine 36 of C-C chemokine receptor type 6 (6 and 36 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6wwz
Structure name
cryo-em structure of the human chemokine receptor ccr6 in complex with ccl20 and a go protein
Structure deposition date
2020-05-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 20
Peptide B name
C-C chemokine receptor type 6
Peptide A accession
P78556
Peptide B accession
P51684
Peptide A residue number
32
Peptide B residue number
36
Ligandability
Cysteine 32 of C-C motif chemokine 20
Cysteine 36 of C-C chemokine receptor type 6
6wwz C 48 R 36
A redox-regulated disulphide may form between cysteine 74 of C-C motif chemokine 20 and cysteine 36 of C-C chemokine receptor type 6 (48 and 36 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6wwz
Structure name
cryo-em structure of the human chemokine receptor ccr6 in complex with ccl20 and a go protein
Structure deposition date
2020-05-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 20
Peptide B name
C-C chemokine receptor type 6
Peptide A accession
P78556
Peptide B accession
P51684
Peptide A residue number
74
Peptide B residue number
36
Ligandability
Cysteine 74 of C-C motif chemokine 20
Cysteine 36 of C-C chemokine receptor type 6
6wwz C 7 R 288
A redox-regulated disulphide may form between cysteine 33 of C-C motif chemokine 20 and cysteine 288 of C-C chemokine receptor type 6 (7 and 288 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6wwz
Structure name
cryo-em structure of the human chemokine receptor ccr6 in complex with ccl20 and a go protein
Structure deposition date
2020-05-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 20
Peptide B name
C-C chemokine receptor type 6
Peptide A accession
P78556
Peptide B accession
P51684
Peptide A residue number
33
Peptide B residue number
288
Ligandability
Cysteine 33 of C-C motif chemokine 20
Cysteine 288 of C-C chemokine receptor type 6
7t1e B 6 B 32
A redox-regulated disulphide may form within C-C motif chemokine 20 between cysteines 32 and 58 (6 and 32 respectively in this structure).
Details
Redox score ?
87
PDB code
7t1e
Structure name
structure of monomeric and dimeric human ccl20
Structure deposition date
2021-12-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78556
Residue number A
32
Residue number B
58
Peptide name
C-C motif chemokine 20
Ligandability
Cysteine 32 of C-C motif chemokine 20
Cysteine 58 of C-C motif chemokine 20
2hci A 7 A 48
A redox-regulated disulphide may form within C-C motif chemokine 20 between cysteines 33 and 74 (7 and 48 respectively in this structure).
Details
Redox score ?
84
PDB code
2hci
Structure name
structure of human mip-3a chemokine
Structure deposition date
2006-06-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78556
Residue number A
33
Residue number B
74
Peptide name
C-C motif chemokine 20
Ligandability
Cysteine 33 of C-C motif chemokine 20
Cysteine 74 of C-C motif chemokine 20
7t1e B 7 B 32
A redox-regulated disulphide may form within C-C motif chemokine 20 between cysteines 33 and 58 (7 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7t1e
Structure name
structure of monomeric and dimeric human ccl20
Structure deposition date
2021-12-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78556
Residue number A
33
Residue number B
58
Peptide name
C-C motif chemokine 20
Ligandability
Cysteine 33 of C-C motif chemokine 20
Cysteine 58 of C-C motif chemokine 20
2hci A 6 A 7
A redox-regulated disulphide may form within C-C motif chemokine 20 between cysteines 32 and 33 (6 and 7 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
2hci
Structure name
structure of human mip-3a chemokine
Structure deposition date
2006-06-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78556
Residue number A
32
Residue number B
33
Peptide name
C-C motif chemokine 20
Ligandability
Cysteine 32 of C-C motif chemokine 20
Cysteine 33 of C-C motif chemokine 20
7t1e B 6 B 48
A redox-regulated disulphide may form within C-C motif chemokine 20 between cysteines 32 and 74 (6 and 48 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7t1e
Structure name
structure of monomeric and dimeric human ccl20
Structure deposition date
2021-12-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78556
Residue number A
32
Residue number B
74
Peptide name
C-C motif chemokine 20
Ligandability
Cysteine 32 of C-C motif chemokine 20
Cysteine 74 of C-C motif chemokine 20
7t1e D 32 D 48
A redox-regulated disulphide may form within C-C motif chemokine 20 between cysteines 58 and 74 (32 and 48 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7t1e
Structure name
structure of monomeric and dimeric human ccl20
Structure deposition date
2021-12-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P78556
Residue number A
58
Residue number B
74
Peptide name
C-C motif chemokine 20
Ligandability
Cysteine 58 of C-C motif chemokine 20
Cysteine 74 of C-C motif chemokine 20
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