ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class II antigen

Intramolecular
Cysteine 44 and cysteine 108
Cysteine 146 and cysteine 202
A redox-regulated disulphide may form within MHC class II antigen between cysteines 44 and 108 (15 and 79 respectively in this structure).

Details

Redox score ?
79
PDB code
6bir
Structure name
hla-drb1 in complex with citrullinated vimentin peptide
Structure deposition date
2017-11-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P79552
Residue number A
44
Residue number B
108
Peptide name
MHC class II antigen

Ligandability

Cysteine 44 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class II antigen between cysteines 146 and 202 (117 and 173 respectively in this structure).

Details

Redox score ?
79
PDB code
6bir
Structure name
hla-drb1 in complex with citrullinated vimentin peptide
Structure deposition date
2017-11-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P79552
Residue number A
146
Residue number B
202
Peptide name
MHC class II antigen

Ligandability

Cysteine 146 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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