C-C motif chemokine 8
Intermolecular
Cysteine 34 and cysteine 34
Cysteine 59 and cysteine 34
Intramolecular
Cysteine 35 and cysteine 75
Cysteine 35 and cysteine 59
Cysteine 34 and cysteine 35
Cysteine 59 and cysteine 75
Cysteine 34 and cysteine 75
7s5a A 11 B 11
A redox-regulated disulphide may form between two units of C-C motif chemokine 8 at cysteines 34 and 34 (11 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7s5a
Structure name
crystal structure of human chemokine ccl8
Structure deposition date
2021-09-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 8
Peptide B name
C-C motif chemokine 8
Peptide A accession
P80075
Peptide B accession
P80075
Peptide A residue number
34
Peptide B residue number
34
Ligandability
7s5a A 36 B 11
A redox-regulated disulphide may form between two units of C-C motif chemokine 8 at cysteines 59 and 34 (36 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7s5a
Structure name
crystal structure of human chemokine ccl8
Structure deposition date
2021-09-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 8
Peptide B name
C-C motif chemokine 8
Peptide A accession
P80075
Peptide B accession
P80075
Peptide A residue number
59
Peptide B residue number
34
Ligandability
Cysteine 59 of C-C motif chemokine 8
Cysteine 34 of C-C motif chemokine 8
1esr A 12 A 52
A redox-regulated disulphide may form within C-C motif chemokine 8 between cysteines 35 and 75 (12 and 52 respectively in this structure).
Details
Redox score ?
83
PDB code
1esr
Structure name
crystal structure of human monocyte chemotactic protein-2
Structure deposition date
2000-04-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80075
Residue number A
35
Residue number B
75
Peptide name
C-C motif chemokine 8
Ligandability
Cysteine 35 of C-C motif chemokine 8
Cysteine 75 of C-C motif chemokine 8
7s5a B 12 B 36
A redox-regulated disulphide may form within C-C motif chemokine 8 between cysteines 35 and 59 (12 and 36 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7s5a
Structure name
crystal structure of human chemokine ccl8
Structure deposition date
2021-09-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80075
Residue number A
35
Residue number B
59
Peptide name
C-C motif chemokine 8
Ligandability
Cysteine 35 of C-C motif chemokine 8
Cysteine 59 of C-C motif chemokine 8
7s5a A 11 A 12
A redox-regulated disulphide may form within C-C motif chemokine 8 between cysteines 34 and 35 (11 and 12 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7s5a
Structure name
crystal structure of human chemokine ccl8
Structure deposition date
2021-09-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80075
Residue number A
34
Residue number B
35
Peptide name
C-C motif chemokine 8
Ligandability
Cysteine 34 of C-C motif chemokine 8
Cysteine 35 of C-C motif chemokine 8
7s5a B 36 B 52
A redox-regulated disulphide may form within C-C motif chemokine 8 between cysteines 59 and 75 (36 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7s5a
Structure name
crystal structure of human chemokine ccl8
Structure deposition date
2021-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80075
Residue number A
59
Residue number B
75
Peptide name
C-C motif chemokine 8
Ligandability
Cysteine 59 of C-C motif chemokine 8
Cysteine 75 of C-C motif chemokine 8
7s5a B 11 B 52
A redox-regulated disulphide may form within C-C motif chemokine 8 between cysteines 34 and 75 (11 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7s5a
Structure name
crystal structure of human chemokine ccl8
Structure deposition date
2021-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80075
Residue number A
34
Residue number B
75
Peptide name
C-C motif chemokine 8
Ligandability
Cysteine 34 of C-C motif chemokine 8
Cysteine 75 of C-C motif chemokine 8
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