C-C motif chemokine 7
Intermolecular
Cysteine 38 of Evasin P974 and cysteine 75
Cysteine 38 of Evasin P974 and cysteine 35
Intramolecular
Cysteine 34 and cysteine 59
Cysteine 35 and cysteine 75
Cysteine 35 and cysteine 59
Cysteine 34 and cysteine 35
Cysteine 59 and cysteine 75
Cysteine 34 and cysteine 75
7s59 3 9 4 52
A redox-regulated disulphide may form between cysteine 38 of Evasin P974 and cysteine 75 of C-C motif chemokine 7 (9 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7s59
Structure name
crystal structure of the tick evasin eva-p974 complexed to a chimera made of human chemokines ccl7 and ccl8
Structure deposition date
2021-09-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
Evasin P974
Peptide B name
C-C motif chemokine 7
Peptide A accession
A0A023FDY8
Peptide B accession
P80098
Peptide A residue number
38
Peptide B residue number
75
Ligandability
Cysteine 38 of Evasin P974
Cysteine 75 of C-C motif chemokine 7
7s58 B 9 E 12
A redox-regulated disulphide may form between cysteine 38 of Evasin P974 and cysteine 35 of C-C motif chemokine 7 (9 and 12 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7s58
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl7
Structure deposition date
2021-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
Evasin P974
Peptide B name
C-C motif chemokine 7
Peptide A accession
A0A023FDY8
Peptide B accession
P80098
Peptide A residue number
38
Peptide B residue number
35
Ligandability
Cysteine 38 of Evasin P974
Cysteine 35 of C-C motif chemokine 7
7s58 H 11 H 36
A redox-regulated disulphide may form within C-C motif chemokine 7 between cysteines 34 and 59 (11 and 36 respectively in this structure).
Details
Redox score ?
81
PDB code
7s58
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl7
Structure deposition date
2021-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80098
Residue number A
34
Residue number B
59
Peptide name
C-C motif chemokine 7
Ligandability
Cysteine 34 of C-C motif chemokine 7
Cysteine 59 of C-C motif chemokine 7
7s58 H 12 H 52
A redox-regulated disulphide may form within C-C motif chemokine 7 between cysteines 35 and 75 (12 and 52 respectively in this structure).
Details
Redox score ?
80
PDB code
7s58
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl7
Structure deposition date
2021-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80098
Residue number A
35
Residue number B
75
Peptide name
C-C motif chemokine 7
Ligandability
Cysteine 35 of C-C motif chemokine 7
Cysteine 75 of C-C motif chemokine 7
7s58 H 12 H 36
A redox-regulated disulphide may form within C-C motif chemokine 7 between cysteines 35 and 59 (12 and 36 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7s58
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl7
Structure deposition date
2021-09-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80098
Residue number A
35
Residue number B
59
Peptide name
C-C motif chemokine 7
Ligandability
Cysteine 35 of C-C motif chemokine 7
Cysteine 59 of C-C motif chemokine 7
7s58 E 11 E 12
A redox-regulated disulphide may form within C-C motif chemokine 7 between cysteines 34 and 35 (11 and 12 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7s58
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl7
Structure deposition date
2021-09-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80098
Residue number A
34
Residue number B
35
Peptide name
C-C motif chemokine 7
Ligandability
Cysteine 34 of C-C motif chemokine 7
Cysteine 35 of C-C motif chemokine 7
7s58 E 36 E 52
A redox-regulated disulphide may form within C-C motif chemokine 7 between cysteines 59 and 75 (36 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7s58
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl7
Structure deposition date
2021-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80098
Residue number A
59
Residue number B
75
Peptide name
C-C motif chemokine 7
Ligandability
Cysteine 59 of C-C motif chemokine 7
Cysteine 75 of C-C motif chemokine 7
7s58 J 11 J 52
A redox-regulated disulphide may form within C-C motif chemokine 7 between cysteines 34 and 75 (11 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7s58
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl7
Structure deposition date
2021-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P80098
Residue number A
34
Residue number B
75
Peptide name
C-C motif chemokine 7
Ligandability
Cysteine 34 of C-C motif chemokine 7
Cysteine 75 of C-C motif chemokine 7
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