ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mitogen-activated protein kinase kinase kinase 9

Intermolecular
Cysteine 421 and cysteine 421
Intramolecular
Cysteine 210 and cysteine 217
A redox-regulated disulphide may form between two units of Mitogen-activated protein kinase kinase kinase 9 at cysteines 421 and 421.

Details

Redox score ?
81
PDB code
4uy9
Structure name
structure of mlk1 kinase domain with leucine zipper 1
Structure deposition date
2014-08-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide A name
Mitogen-activated protein kinase kinase kinase 9
Peptide B name
Mitogen-activated protein kinase kinase kinase 9
Peptide A accession
P80192
Peptide B accession
P80192
Peptide A residue number
421
Peptide B residue number
421

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 9 between cysteines 210 and 217.

Details

Redox score ?
69
PDB code
4uy9
Structure name
structure of mlk1 kinase domain with leucine zipper 1
Structure deposition date
2014-08-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
52
Peptide accession
P80192
Residue number A
210
Residue number B
217
Peptide name
Mitogen-activated protein kinase kinase kinase 9

Ligandability

Cysteine 210 of Mitogen-activated protein kinase kinase kinase 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Mitogen-activated protein kinase kinase kinase 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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