G-protein-signaling modulator 2
Intermolecular
Cysteine 124 and cysteine 604
Cysteine 161 and cysteine 1907 of Nuclear mitotic apparatus protein 1
Cysteine 614 and cysteine 125
Cysteine 604 and cysteine 125
Intramolecular
Cysteine 35 and cysteine 40
Cysteine 124 and cysteine 125
4jhr A 117 B 597
A redox-regulated disulphide may form between two units of G-protein-signaling modulator 2 at cysteines 124 and 604 (117 and 597 respectively in this structure).
Details
Redox score ?
82
PDB code
4jhr
Structure name
an auto-inhibited conformation of lgn reveals a distinct interaction mode between goloco motifs and tpr motifs
Structure deposition date
2013-03-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide A name
G-protein-signaling modulator 2
Peptide B name
G-protein-signaling modulator 2
Peptide A accession
Q8VDU0
Peptide B accession
Q8VDU0
Peptide A residue number
124
Peptide B residue number
604
Ligandability
Cysteine 124 of G-protein-signaling modulator 2
Cysteine 604 of G-protein-signaling modulator 2
6hc2 Q 154 R 1907
A redox-regulated disulphide may form between cysteine 161 of G-protein-signaling modulator 2 and cysteine 1907 of Nuclear mitotic apparatus protein 1 (154 and 1907 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
6hc2
Structure name
crystal structure of numa/lgn hetero-hexamers
Structure deposition date
2018-08-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
56
Peptide A name
G-protein-signaling modulator 2
Peptide B name
Nuclear mitotic apparatus protein 1
Peptide A accession
P81274
Peptide B accession
Q14980
Peptide A residue number
161
Peptide B residue number
1907
Ligandability
Cysteine 161 of G-protein-signaling modulator 2
Cysteine 1907 of Nuclear mitotic apparatus protein 1
4jhr A 607 B 118
A redox-regulated disulphide may form between two units of G-protein-signaling modulator 2 at cysteines 614 and 125 (607 and 118 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
4jhr
Structure name
an auto-inhibited conformation of lgn reveals a distinct interaction mode between goloco motifs and tpr motifs
Structure deposition date
2013-03-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
96
Peptide A name
G-protein-signaling modulator 2
Peptide B name
G-protein-signaling modulator 2
Peptide A accession
Q8VDU0
Peptide B accession
Q8VDU0
Peptide A residue number
614
Peptide B residue number
125
Ligandability
Cysteine 614 of G-protein-signaling modulator 2
Cysteine 125 of G-protein-signaling modulator 2
4jhr A 597 B 118
A redox-regulated disulphide may form between two units of G-protein-signaling modulator 2 at cysteines 604 and 125 (597 and 118 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4jhr
Structure name
an auto-inhibited conformation of lgn reveals a distinct interaction mode between goloco motifs and tpr motifs
Structure deposition date
2013-03-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
nan
Peptide A name
G-protein-signaling modulator 2
Peptide B name
G-protein-signaling modulator 2
Peptide A accession
Q8VDU0
Peptide B accession
Q8VDU0
Peptide A residue number
604
Peptide B residue number
125
Ligandability
Cysteine 604 of G-protein-signaling modulator 2
Cysteine 125 of G-protein-signaling modulator 2
3sf4 A 28 A 33
A redox-regulated disulphide may form within G-protein-signaling modulator 2 between cysteines 35 and 40 (28 and 33 respectively in this structure).
Details
Redox score ?
82
PDB code
3sf4
Structure name
crystal structure of the complex between the conserved cell polarity proteins inscuteable and lgn
Structure deposition date
2011-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
7
% buried
58
Peptide accession
P81274
Residue number A
35
Residue number B
40
Peptide name
G-protein-signaling modulator 2
Ligandability
Cysteine 35 of G-protein-signaling modulator 2
Cysteine 40 of G-protein-signaling modulator 2
4g2v A 117 A 118
A redox-regulated disulphide may form within G-protein-signaling modulator 2 between cysteines 124 and 125 (117 and 118 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4g2v
Structure name
structure complex of lgn binding with frmpd1
Structure deposition date
2012-07-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
87
Peptide accession
Q8VDU0
Residue number A
124
Residue number B
125
Peptide name
G-protein-signaling modulator 2
Ligandability
Cysteine 124 of G-protein-signaling modulator 2
Cysteine 125 of G-protein-signaling modulator 2
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