ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

28S ribosomal protein S25, mitochondrial

Intermolecular
Cysteine 26 of 28S ribosomal protein S16, mitochondrial and cysteine 149 L
Cysteine 26 of 28S ribosomal protein S16, mitochondrial and cysteine 141 L
Cysteine 26 of 28S ribosomal protein S16, mitochondrial and cysteine 139 L
Intramolecular
Cysteine 141 and cysteine 149 L
Cysteine 139 and cysteine 141 L
Cysteine 139 and cysteine 149 L
A redox-regulated disulphide may form between cysteine 26 of 28S ribosomal protein S16, mitochondrial and cysteine 149 of 28S ribosomal protein S25, mitochondrial.

Details

Redox score ?
90
PDB code
8csp
Structure name
human mitochondrial small subunit assembly intermediate (state a)
Structure deposition date
2022-05-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
3
% buried
64
Peptide A name
28S ribosomal protein S16, mitochondrial
Peptide B name
28S ribosomal protein S25, mitochondrial
Peptide A accession
Q9Y3D3
Peptide B accession
P82663
Peptide A residue number
26
Peptide B residue number
149

Ligandability

Cysteine 26 of 28S ribosomal protein S16, mitochondrial

Cysteine 149 of 28S ribosomal protein S25, mitochondrial

A redox-regulated disulphide may form between cysteine 26 of 28S ribosomal protein S16, mitochondrial and cysteine 141 of 28S ribosomal protein S25, mitochondrial.

Details

Redox score ?
73
PDB code
3jd5
Structure name
cryo-em structure of the small subunit of the mammalian mitochondrial ribosome
Structure deposition date
2016-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
36
Peptide A name
28S ribosomal protein S16, mitochondrial
Peptide B name
28S ribosomal protein S25, mitochondrial
Peptide A accession
P82915
Peptide B accession
P82669
Peptide A residue number
26
Peptide B residue number
141

Ligandability

Cysteine 26 of 28S ribosomal protein S16, mitochondrial

Cysteine 141 of 28S ribosomal protein S25, mitochondrial

A redox-regulated disulphide may form between cysteine 26 of 28S ribosomal protein S16, mitochondrial and cysteine 139 of 28S ribosomal protein S25, mitochondrial.

Details

Redox score ?
62
PDB code
8cst
Structure name
human mitochondrial small subunit assembly intermediate (state e)
Structure deposition date
2022-05-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
74
Peptide A name
28S ribosomal protein S16, mitochondrial
Peptide B name
28S ribosomal protein S25, mitochondrial
Peptide A accession
Q9Y3D3
Peptide B accession
P82663
Peptide A residue number
26
Peptide B residue number
139

Ligandability

Cysteine 26 of 28S ribosomal protein S16, mitochondrial

Cysteine 139 of 28S ribosomal protein S25, mitochondrial

A redox-regulated disulphide may form within 28S ribosomal protein S25, mitochondrial between cysteines 141 and 149.

Details

Redox score ?
92
PDB code
8csq
Structure name
human mitochondrial small subunit assembly intermediate (state b)
Structure deposition date
2022-05-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
3
% buried
54
Peptide accession
P82663
Residue number A
141
Residue number B
149
Peptide name
28S ribosomal protein S25, mitochondrial

Ligandability

Cysteine 141 of 28S ribosomal protein S25, mitochondrial

Cysteine 149 of 28S ribosomal protein S25, mitochondrial

A redox-regulated disulphide may form within 28S ribosomal protein S25, mitochondrial between cysteines 139 and 141.

Details

Redox score ?
78
PDB code
6neq
Structure name
structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit-class-ii
Structure deposition date
2018-12-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
66
Peptide accession
P82669
Residue number A
139
Residue number B
141
Peptide name
28S ribosomal protein S25, mitochondrial

Ligandability

Cysteine 139 of 28S ribosomal protein S25, mitochondrial

Cysteine 141 of 28S ribosomal protein S25, mitochondrial

A redox-regulated disulphide may form within 28S ribosomal protein S25, mitochondrial between cysteines 139 and 149.

Details

Redox score ?
71
PDB code
8csr
Structure name
human mitochondrial small subunit assembly intermediate (state c)
Structure deposition date
2022-05-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
2
% buried
70
Peptide accession
P82663
Residue number A
139
Residue number B
149
Peptide name
28S ribosomal protein S25, mitochondrial

Ligandability

Cysteine 139 of 28S ribosomal protein S25, mitochondrial

Cysteine 149 of 28S ribosomal protein S25, mitochondrial

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